PMID: 9167898Apr 1, 1997Paper

HDL3 exerts more powerful anti-oxidative, protective effects against copper-catalyzed LDL oxidation than HDL2

Clinical Biochemistry
M YoshikawaT Fujinami

Abstract

To evaluate which HDL subfraction, HDL2 or HDL3 exerts the greater preventive effect on the Cu(2+)-induced LDL oxidation. LDL was incubated for 6 h with 2.5 microM Cu2+ in phosphate-buffered saline alone, or in the presence of HDL2 or HDL3 at various protein concentrations. Each sample was subjected to agarose gel electrophoresis, and the amount of lipid hydroperoxide in each sample of LDL was measured. There was no significant difference in the levels of LPO between the LDL and LDL + HDL2 cases, whereas a significant reduction was apparent with LDL + HDL3. Both HDL2 and HDL3 significantly inhibited oxidative modification of LDL, as assessed by electrophoretic mobility, in a concentration dependent manner, but this effect was much more pronounced with HDL3. HDL3 may play an important role in the prevention of atherosclerosis in vivo, more effectively inhibiting oxidation of LDL than HDL2.

References

Mar 1, 1990·Chemical Research in Toxicology·H EsterbauerG Jürgens
Oct 1, 1990·Biochemical Pharmacology·R Chander, N K Kapoor
May 22, 1990·Biochimica Et Biophysica Acta·S ParthasarathyL G Fong
Mar 1, 1987·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·U P SteinbrecherD Steinberg
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M T QuinnD Steinberg
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M T QuinnD Steinberg
Jan 1, 1971·Annals of Internal Medicine·W B KannelP M McNamara
Jul 6, 1984·Biochimica Et Biophysica Acta·D E Newton, J M Shaw
Jul 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D W MorelG M Chisolm
Jan 1, 1981·Annals of Nutrition & Metabolism·D R IllingworthP Alaupovic
Mar 1, 1983·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·T HenriksenD Steinberg
Jun 1, 1995·Atherosclerosis·M I Mackness, P N Durrington
Apr 1, 1993·Atherosclerosis·A N KlimovN P Teryukova
Sep 1, 1955·The Journal of Clinical Investigation·R J HAVELJ H BRAGDON

❮ Previous
Next ❯

Citations

Sep 3, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Renzo SchiavonGiancesare Guidi
Dec 1, 2001·Free Radical Biology & Medicine·O RavehD Lichtenberg
Sep 25, 2010·Lipids in Health and Disease·Nakanishi ShuheiMarja-Riitta Taskinen
Nov 27, 2008·Journal of Lipid Research·Kerry-Anne RyePhilip J Barter
Jan 5, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·D Bonnefont-RousselotJ Delattre
Nov 28, 2009·Journal of Atherosclerosis and Thrombosis·Nagahiko SakumaSyuichi Kitada
Apr 4, 2013·Biomarkers in Medicine·Amirnader Emami RazaviGholam Ali Naderi
Nov 2, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Bhagu R Bhavnani, Frank Z Stanczyk
Feb 25, 2014·Free Radical Biology & Medicine·Anthony J ValenteBysani Chandrasekar
Dec 17, 2014·PloS One·Sten Braesch-AndersenMakiko Kumagai-Braesch
Mar 4, 2003·Journal of Lipid Research·Vasilis TsimihodimosAlexandros D Tselepis
Jun 1, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Milind Y DesaiJoão A C Lima
Aug 16, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Anatol KontushM John Chapman
Jan 17, 2013·Stroke; a Journal of Cerebral Circulation·Choy-Lye CheiUNKNOWN CIRCS Investigators
Feb 2, 2008·Nature Reviews. Drug Discovery·Tisha Joy, Robert A Hegele
Jan 1, 2013·Animals : an Open Access Journal From MDPI·Lisa M Collins, Chérie E Part
Jun 13, 2019·Angiology·Eva XepapadakiKyriakos E Kypreos
Feb 22, 2012·Nature Reviews. Endocrinology·Julia C CreiderTisha R Joy
Oct 11, 2005·The Journal of Nutritional Biochemistry·Elena Thomàs-MoyàAna M Proenza
May 17, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sabari DasLalit Mohan Srivastava

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.