HE4 and CA125 as preoperative risk stratifiers for lymph node metastasis in endometrioid carcinoma of the endometrium: A retrospective study in a cohort with histological proof of lymph node status.

Gynecologic Oncology
Sharon A O'TooleNoreen Gleeson

Abstract

To investigate whether HE4 and CA125 could identify endometrioid adenocarcinoma patients who might most benefit from full staging surgery with lymphadenectomy. Sequential patients with a preoperative banked serum and histology of endometrioid adenocarcinoma of endometrium who had undergone surgical staging with lymph node dissection over a 5-year period between 2011 and 2016 were included from a tertiary Gynaecological Cancer Centre, Dublin, Ireland. Preoperative serum HE4 and CA125 were measured using ELISA, with the cut-offs HE4 81 pmol/L and CA125 35 U/ml. Predictive values were estimated using AUC, sensitivity, specificity and odds ratios. 9.5% of the cohort had lymph node metastases. A HE4 cut-off of 81 pmol/L yielded a sensitivity of 78.6% and specificity of 53.4% for predicting lymph node metastases. Sensitivity of CA125 at 35 U/ml was 57% and specificity 91.4%. The AUC was 0.66 (0.52-0.80) for HE4 and 0.74 (0.58-0.91) for CA125. Sensitivity was 92.8% and specificity 51.1% when an elevation of either HE4 or CA125 was included, AUC was 0.72 (0.61-0.83), this combination yielded the highest NPV of 98.6%. Sensitivity was 42.9% and specificity 93.8% if both markers were elevated simultaneously, AUC was 0.68 (0.51-0.86). Preo...Continue Reading

References

Dec 13, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·W T CreasmanS Pecorelli
Nov 23, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Nils BolstadJohan Bjerner
Jun 13, 2012·Annals of Clinical Biochemistry·Béla NagyJános Kappelmayer
Oct 26, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Laura ZanottiAntonella Ravaggi
Nov 28, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Roberto AngioliPierluigi Benedetti-Panici
Aug 29, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Roberto AngioliFrancesco Plotti
Sep 17, 2013·Acta Obstetricia Et Gynecologica Scandinavica·Sofie L AntonsenClaus Høgdall
Sep 27, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Roberto AngioliFrancesco Plotti
Nov 12, 2013·Gynecologic Oncology·Donal J BrennanAndreas Obermair
Jan 30, 2014·The Journal of Obstetrics and Gynaecology Research·Giorgio BoganiAndrea Mariani
Aug 30, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Nikoline S KarlsenEstrid V S Høgdall
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Aug 1, 2015·The Journal of Obstetrics and Gynaecology Research·Lubos MinarJulie Bienertova-Vasku
Sep 8, 2015·Advances in Medical Sciences·Bozena DobrzyckaSlawomir Jerzy Terlikowski
Nov 5, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Roberto AngioliFrancesco Plotti
Jan 15, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Melissa K McConechyJessica N McAlpine
Jan 26, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Lingli HuYing Li
Feb 29, 2016·Current Oncology Reports·Ingfrid S Haldorsen, Helga B Salvesen
Apr 5, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Nisa PrueksaritanondMarut Yanaranop
Jan 19, 2017·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Yingmei WangFengxia Xue
Feb 12, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Gokhan BoyrazKunter Yuce
Sep 9, 2017·Obstetrics and Gynecology·Nicole C M VisserJohanna M A Pijnenborg
Nov 1, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·W T CreasmanS Pecorelli
Oct 16, 2018·Minerva ginecologica·Francesco PlottiRoberto Angioli
Nov 6, 2018·International Journal of Cancer. Journal International Du Cancer·Olivia RaglanMaria Kyrgiou
Aug 23, 2019·Archives of Gynecology and Obstetrics·Yujie LiGuirong Sun
Dec 17, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·L S E ErikssonL Wynants
Mar 10, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Andrea Espiau RomeraLaura Baquedano Mainar

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