HE4 is superior to CA125 in the detection of recurrent disease in high-risk endometrial cancer patients

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Karin AbbinkLeon Fag Massuger

Abstract

To date, biomarkers are not routinely used in endometrial cancer diagnosis, prognosis, and follow-up. The purpose of this study was to evaluate whether serum HE4 was related to clinicopathological risk factors and outcome. Second, the role of serum HE4 and CA125 was assessed as indicator for recurrent disease during follow-up. A total of 174 patients with endometrial cancer between 1999 and 2009 were selected for this retrospective study. Serum HE4 and CA125 were analyzed at primary diagnosis, during follow-up, and at the time of recurrence. Correlations with clinicopathological factors were studied by univariate and multivariate survival analyses. Lead time was calculated in order to determine which serum marker was elevated prior to clinical detection of recurrent disease. Serum levels of HE4 and CA125 were significantly associated with high tumor grade, myometrial invasion, lymph node involvement, and advanced stage (p < 0.01). HE4 was an independent prognostic factor for reduced disease-free survival and overall survival with hazard ratios of 2.96 (95% confidence interval: 1.18-7.99) and 3.27 (95% confidence interval: 1.18-9.02), respectively. At recurrence, 75% of the patients had an elevated HE4 compared to 54% with an el...Continue Reading

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Citations

Mar 10, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Andrea Espiau RomeraLaura Baquedano Mainar
Jan 4, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Manon DegezVincent Dochez
Feb 3, 2021·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Niveditha RajadevanYael Naaman
Nov 7, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Andrea Espiau RomeraLaura Baquedano Mainar
Jun 11, 2021·Archives of Gynecology and Obstetrics·Putsarat InsinNisa Prueksaritanond
Jun 27, 2021·Clinical Oncology : a Journal of the Royal College of Radiologists·A CollinsE L Moss
Jul 3, 2021·Journal of Clinical Medicine·Marketa BednarikovaVit Weinberger

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Methods Mentioned

BETA
X-ray
hysterectomy
biopsy
imaging techniques

Software Mentioned

GraphPad prism
GraphPad

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