Head and neck and esophageal cancers after liver transplant: results from a multicenter cohort study. Italy, 1997-2010

Transplant International : Official Journal of the European Society for Organ Transplantation
Pierluca PiselliItalian Transplant and Cancer Cohort Study

Abstract

This study quantified the risk of head and neck (HN) and esophageal cancers in 2770 Italian liver transplant (LT) recipients. A total of 186 post-transplant cancers were diagnosed-including 32 cases of HN cancers and nine cases of esophageal carcinoma. The 10-year cumulative risk for HN and esophageal carcinoma was 2.59%. Overall, HN cancers were nearly fivefold more frequent in LT recipients than expected (standardized incidence ratios - SIR=4.7, 95% CI: 3.2-6.6), while esophageal carcinoma was ninefold more frequent (SIR=9.1, 95% CI: 4.1-17.2). SIRs ranged from 11.8 in LT with alcoholic liver disease (ALD) to 1.8 for LT without ALD for HN cancers, and from 23.7 to 2.9, respectively, for esophageal carcinoma. Particularly elevated SIRs in LT with ALD were noted for carcinomas of tongue (23.0) or larynx (13.7). Our findings confirmed and quantified the large cancer excess risk in LT recipients with ALD. The risk magnitude and the prevalence of ALD herein documented stress the need of timely and specifically organized programs for the early diagnosis of cancer among LT recipients, particularly for high-risk recipients like those with ALD.

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Citations

Apr 21, 2016·The Medical Clinics of North America·Iliana DoychevaKymberly D Watt
Apr 26, 2018·International Journal of Cancer. Journal International Du Cancer·Martina TaborelliUNKNOWN Italian Transplant & Cancer Cohort Study
Aug 10, 2018·International Journal of Cancer. Journal International Du Cancer·Martina TaborelliUNKNOWN Italian Transplant and Cancer Cohort Study
Jan 13, 2018·Current Opinion in Organ Transplantation·Patrizia BurraAlberto Zanetto
Sep 29, 2019·World Journal of Gastroenterology : WJG·Tommaso Maria ManziaLeonardo Baiocchi
Jan 26, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Sarah ShalabyUNKNOWN Italian Transplant and Cancer Cohort Study
Jul 25, 2021·British Dental Journal·Andreea Cristiana DidilescuHendrik Simon Brand

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