Head and neck cancer in young people: a series of 52 SCCs of the oral tongue in patients aged 35 years or less

Acta Oto-laryngologica
Yann MalletCharles Fournier

Abstract

Prognosis was very poor as soon as a local failure developed. Up-front treatment should be optimized to control this rare disease. We propose producing and reporting recommendations via a concerted oncologic physician referral network. Squamous cell carcinoma (SCC) in young people is rare and the literature is confusing. This study was carried out to assess the demographics, clinical features, and treatment outcome in a cohort of patients aged 35 years or less with SCC of the oral tongue (SCCOT). This was a multicenter retrospective study. Fifty-two patients treated between 1990 and 2000 were identified. Descriptive statistics were analyzed to assess demographic and tumor variables. The WHO performance status was excellent for all patients. Thirty-seven were classified as T1-T2 and 38 were N0. All of them except one were treated with curative intent. Treatment failures were observed in 25 patients (48%). Four patients could be successfully salvaged after SCCOT recurrence or progression. The disease-free survival (DFS) was 52% at 5 years. The 5-year overall survival (OS) rate was 64%. Factors that affected the OS were invasion of the floor (p=0.009), cross over of the midline (p=0.02), positive lymph nodes (p=0.02), and the lack...Continue Reading

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Citations

Jan 15, 2015·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Janaina Almeida MesquitaPollianna Muniz Alves
Jun 4, 2013·The Laryngoscope·Amy Anne D LassigBevan Yueh
Mar 13, 2016·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·P BlanchardY Tao
Sep 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Negar MafiAli Zare-Mirzaie
Jul 23, 2019·Head & Neck·Jennifer Le GuevelouJuliette Thariat
Apr 8, 2018·Head & Neck·Daniel Cohen GoldembergLuiz Claudio Santos Thuler
Jan 17, 2020·Journal of Oral and Maxillofacial Pathology : JOMFP·Khadijah MohideenS Leena Sankari
Apr 21, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Sophie DeneuveUNKNOWN GETTEC

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