Head and neck manifestations of the immune reconstitution syndrome in HIV-infected patients: a cohort study

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Yuria Ablanedo-TerrazasGustavo Reyes-Terán

Abstract

To describe head and neck manifestations of immune reconstitution inflammatory syndrome (IRIS) in a cohort of HIV-infected patients receiving combined antiretroviral therapy (cART). After initiation of cART, some HIV-infected patients present a paradoxical worsening and clinical deterioration due to pathological inflammatory reactions to infectious or noninfectious antigens, a condition known as IRIS. Prospective study with a follow-up period of 6 to 24 months. Tertiary referral center in Mexico City. Our cohort was integrated by 165 patients who had started cART within the past 2 months prior to study entry. Patients underwent a complete ear, nose, and throat examination (ENT). Laboratory tests (hematology and blood chemistry), cultures from body fluids, and biopsies were performed. Of the 165 patients studied, 21 (12.7%) presented IRIS in the head and neck region. Kaposi sarcoma was the most common presentation, observed in 7 patients. Tuberculosis-associated IRIS was observed in 6 patients with scrophulas, lymph node enlargement, or retropharyngeal abscess. Other manifestations included herpes simplex I infection and unilateral vocal fold palsy secondary to Mycobacterium avium intracelulare paratracheal abscess and scrophula...Continue Reading

References

Oct 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter PhillipsJulio Montaner
Oct 20, 2005·AIDS Patient Care and STDs·Rom S Leidner, David M Aboulafia
Dec 16, 2005·The Journal of Antimicrobial Chemotherapy·Samuel A ShelburneRichard J Hamill
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Jul 26, 2008·The Lancet Infectious Diseases·Graeme MeintjesUNKNOWN International Network for the Study of HIV-associated IRIS
Dec 6, 2008·Biomarkers in Medicine·Shuli BonhamDavid R Boulware
Mar 26, 2010·The Lancet Infectious Diseases·Monika MüllerUNKNOWN IeDEA Southern and Central Africa

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Citations

Mar 23, 2013·Oral Diseases·L L PattonK Ranganathan
Sep 16, 2017·Journal of the International Association of Providers of AIDS Care·Anandit MuSimon Paul
Mar 29, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A MelzaniA Adenis

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Methods Mentioned

BETA
biopsy

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