Head and neck paragangliomas: clinical and molecular genetic classification.

Clinics
Christian OffergeldHartmut P H Neumann

Abstract

Head and neck paragangliomas are tumors arising from specialized neural crest cells. Prominent locations are the carotid body along with the vagal, jugular, and tympanic glomus. Head and neck paragangliomas are slowly growing tumors, with some carotid body tumors being reported to exist for many years as a painless lateral mass on the neck. Symptoms depend on the specific locations. In contrast to paraganglial tumors of the adrenals, abdomen and thorax, head and neck paragangliomas seldom release catecholamines and are hence rarely vasoactive. Petrous bone, jugular, and tympanic head and neck paragangliomas may cause hearing loss. The internationally accepted clinical classifications for carotid body tumors are based on the Shamblin Class I-III stages, which correspond to postoperative permanent side effects. For petrous-bone paragangliomas in the head and neck, the Fisch classification is used. Regarding the molecular genetics, head and neck paragangliomas have been associated with nine susceptibility genes: NF1, RET, VHL, SDHA, SDHB, SDHC, SDHD, SDHAF2 (SDH5), and TMEM127. Hereditary HNPs are mostly caused by mutations of the SDHD gene, but SDHB and SDHC mutations are not uncommon in such patients. Head and neck paraganglioma...Continue Reading

Citations

Mar 19, 2014·American Journal of Otolaryngology·Julian KünzelHeinrich Iro
Jan 12, 2019·Case Reports in Otolaryngology·James H KimBozena Barbara Wrobel
Feb 23, 2020·Case Reports in Endocrinology·Alejandro Terrones-LozanoLesly Portocarrero-Ortiz
Jul 21, 2020·Case Reports in Otolaryngology·Elizabeth A SchuethJonathan Y Ting
Feb 26, 2015·Head and Neck Pathology·Erin R S HamersleyJames T Castle
Oct 28, 2016·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Santhosh GaddikeriYoshimi Anzai
Aug 15, 2017·Clinical Nuclear Medicine·Neva GirottoPetra Valković-Zujić
Mar 6, 2018·BMC Medical Genomics·Anastasiya V SnezhkinaAnna V Kudryavtseva
Sep 23, 2018·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·R SchneiderJ Ukkat
Dec 14, 2018·Journal of Neurosurgery. Pediatrics·Manish KuchakullaToba N Niazi
May 23, 2019·Head & Neck·Kartsunori KatagiriKazuyuki Ishida
Jul 13, 2019·Vascular Specialist International·Thomas Kotsis, Panagitsa Christoforou
Apr 10, 2019·Case Reports in Vascular Medicine·Thomas KotsisConstantinos Nastos
Apr 25, 2014·São Paulo Medical Journal = Revista Paulista De Medicina·André Luís Maion CasarimAntonio Santos Martins
Jun 30, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·T AnttilaL J Bäck
Mar 15, 2018·Journal of Clinical Medicine·Ali HaratiThomas Deitmer
May 20, 2017·Biomedicine Hub·Juliana Maria de Almeida VitalArli Regina Lopes Moraes
Sep 20, 2020·BMC Medical Genomics·Anna V KudryavtsevaAnastasiya V Snezhkina
Dec 1, 2015·Archives of Pathology & Laboratory Medicine·Kathleen T Montone
Nov 7, 2015·SpringerPlus·G BanoS Hodgson
Jun 17, 2015·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Paweena LertakyamaneeJonathan D Trobe
Nov 10, 2017·BMC Ear, Nose, and Throat Disorders·Bishow Tulachan, Buddha Nath Borgohain
Mar 20, 2018·Oncology Letters·Aya IkedaKen-Ichi Kaneko
Mar 5, 2019·Insights Into Imaging·Jarett Thelen, Alok A Bhatt
Jul 17, 2015·Diagnostic Cytopathology·Wei Zhang, Maria Luisa C Policarpio-Nicolas
Mar 23, 2017·Head and Neck Pathology·Michelle D Williams
Jul 4, 2017·The Annals of Otology, Rhinology, and Laryngology·Parul SinhaBruce H Haughey
Mar 22, 2019·The Journal of Craniofacial Surgery·Binbin Zhu, Jianhua Yan
Jun 23, 2016·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Andrzej MarszałekSławomir Wiśniewski
Mar 4, 2021·Journal of Clinical Imaging Science·Ashley Renay WayDinesh Rao
May 4, 2021·Journal of Surgical Case Reports·Natesh YepuriSudhakar Kinthala
May 19, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Yoshiaki OtaAshok Srinivasan
Jun 8, 2021·Annals of Medicine and Surgery·Boutaina MerzouqiMohamed Mahtar
Jul 15, 2021·HNO·Ann-Kathrin RauchChristian Offergeld

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging technique
surgical resection

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Expert Review of Anticancer Therapy
Liang ChengAntonio Lopez-Beltran
Fetal and Pediatric Pathology
Seyfettin UludagSezin Uludag
© 2021 Meta ULC. All rights reserved