Head and neck region consolidation radiotherapy and prophylactic cranial irradiation with hippocampal avoidance delivered with helical tomotherapy after induction chemotherapy for non-sinonasal neuroendocrine carcinoma of the upper airways.

Radiation Oncology
Pierfrancesco FrancoUmberto Ricardi

Abstract

Non-sinonasal neuroendocrine carcinomas (NSNECs) of the head and neck are considered an unfrequent clinico-pathological entity. Combined modality treatment represents an established therapeutic option for undifferentiated forms where distant metastasis is a common pattern of failure. We report on a case of NSNEC treated with sequential chemo-radiation consisting of 6 cycles of cisplatin and etoposide followed by loco-regional radiation to the head and neck and simultaneous prophylactic cranial irradiation to prevent from intracranial spread, delivered with helical tomotherapy with the 'hippocampal avoidance' technique in order to reduce neuro-cognitive late effects. One year after the end of the whole combined modality approach, the patient achieved complete remission, with no treatment-related sub-acute and late effects. The present report highlights the importance of multidisciplinary management for NSNECs of the head and neck, as the possibility to achieve substantial cure rates with mild side effects with modern radiotherapy techniques.

References

Oct 15, 1984·Cancer·N B IbrahimC M Corbishley
Apr 10, 1999·Seminars in Radiation Oncology·T R MackieM Mehta
Apr 20, 1999·Archives of Otolaryngology--head & Neck Surgery·K T Robbins
Jun 21, 2002·Current Treatment Options in Oncology·Robin P Boushey, Alan P B Dackiw
Aug 13, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christina A Meyers, Jeffrey S Wefel
Nov 25, 2003·Cancer·Jerry L BarkerDavid I Rosenthal
Mar 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christina A Meyers, Paul D Brown
May 8, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Renzo Corvò
May 8, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jacek Jassem
Mar 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Charles MayoJohn Kirkpatrick
Mar 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Niranjan BhandareWilliam M Mendenhall
Mar 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Joseph O DeasyAvraham Eisbruch
Mar 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Tiziana RancatiAvraham Eisbruch
Apr 16, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Vinai GondiMinesh P Mehta
Oct 26, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Vinai GondiMinesh P Mehta
Mar 26, 2011·Behavioural Brain Research·Tsung-Hsun HsiehHsiao-Yu Lee
Jul 29, 2011·Head & Neck Oncology·Anna LikhachevaAdel K El-Naggar

❮ Previous
Next ❯

Citations

Jan 24, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·F OskanM Niyazi
Mar 19, 2014·Current Medical Research and Opinion·Ozan YazıcıNurullah Zengin
Feb 24, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Silvia ScocciantiLorenzo Livi

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

QUANTEC
CTCAE
Oncentra Masterplan

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
A FiorentinoV Fusco
Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists
George RodriguesG Bauman
Clinical Nuclear Medicine
Punit SharmaRakesh Kumar
Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Gary V WalkerClifton David Fuller
© 2022 Meta ULC. All rights reserved