Head and trunk stability during gait before and after levodopa intake in Parkinson's disease subtypes

Experimental Gerontology
Paulo H S PelicioniStephen R Lord

Abstract

People with Parkinson's disease (PD) can be classified into tremor dominant (TD) and postural instability and gait difficulty (PIGD) subtypes; the latter group having more impaired gait and increased fall risk. While there is some evidence that anti-parkinsonian medication, levodopa, might not improve balance and gait control or reduce fall risk in the PIGD subtype, it is unclear whether the levodopa dosage intake affects gait stability. To address these issues, this study used accelerometry to compare gait stability: (i) during before and after levodopa intake between non-PIGD and PIGD subtypes; (ii) between individuals who took less or >750 mg of levodopa/day. In 15 non-PIGD (Combination of 13 TD patients and 2 classified as indeterminate subtype) and 23 PIGD participants of similar mean (SD) age ((63.0 (7.6) versus 62.6 (10.0) years, respectively)) and disease-duration (8.9 (8.9) versus 11.3 (4.6) years, respectively), head and trunk stability during gait was examined using anteroposterior, vertical and mediolateral acceleration harmonic ratios (HRs). Participants were assessed before and after a levodopa dose, during typical "off" and "on" periods, respectively. Two-way analyses of variance (group × medication status) revea...Continue Reading

Citations

May 14, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Christian MeyerLinard Filli
Jun 27, 2019·International Journal of Environmental Research and Public Health·Paulo H S PelicioniStephen R Lord
Dec 2, 2020·The International Journal of Neuroscience·Lin MaPiu Chan
Aug 12, 2021·Journal of Neuroengineering and Rehabilitation·Zachary J ConwayMichael H Cole
Sep 11, 2021·Neurorehabilitation and Neural Repair·Samuel StuartMartina Mancini

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