Head Direction Cell Activity Is Absent in Mice without the Horizontal Semicircular Canals

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Stephane Valerio, Jeffrey S Taube

Abstract

Head direction (HD) cells fire when an animal faces a particular direction in its environment, and they are thought to represent the neural correlate of the animal's perceived spatial orientation. Previous studies have shown that vestibular information is critical for generating the HD signal but have not delineated whether information from all three semicircular canals or just the horizontal canals, which are primarily sensitive to angular head rotation in the horizontal (yaw) plane, are critical for the signal. Here, we monitored cell activity in the anterodorsal thalamus (ADN), an area known to contain HD cells, in epstatic circler (Ecl) mice, which have a bilateral malformation of the horizontal (lateral) semicircular canals. Ecl mice and their littermates that did not express the mutation (controls) were implanted with recording electrodes in the ADN. Results confirm the important role the horizontal canals play in forming the HD signal. Although normal HD cell activity (Raleigh's r > 0.4) was recorded in control mice, no such activity was found in Ecl mice, although some cells had activity that was mildly modulated by HD (0.4 > r > 0.2). Importantly, we also observed activity in Ecl mice that was best characterized as bur...Continue Reading

Citations

Jul 12, 2016·Current Biology : CB·Adrienn G Varga, Roy E Ritzmann
Apr 22, 2017·Nature Reviews. Neurology·Thomas Brandt, Marianne Dieterich
Dec 13, 2016·Current Opinion in Neurology·Thomas BrandtStefan Glasauer
Jul 21, 2017·Nature Communications·Jean SimonnetDesdemona Fricker
Mar 8, 2018·The European Journal of Neuroscience·Johannes PasseckerShane M O'Mara
Mar 7, 2018·Experimental Brain Research·Vivekanand Pandey VimalPaul DiZio
Nov 1, 2018·Journal of Neurophysiology·Michael E Shinder, Jeffrey S Taube
Jan 1, 2018·Network : Computation in Neural Systems·Hector J I PageSimon M Stringer
Nov 24, 2017·Journal of Neurophysiology·Phillip AitkenPaul F Smith
Mar 27, 2020·Journal of Neurophysiology·Jeffrey S Taube, Michael E Shinder
Dec 25, 2019·Annual Review of Neuroscience·Brad K Hulse, Vivek Jayaraman
Aug 29, 2020·Annals of Clinical and Translational Neurology·Julian ConradMarianne Dieterich
Dec 14, 2018·Frontiers in Cellular Neuroscience·Zhixian Cheng, Yong Gu
Feb 9, 2021·Experimental Brain Research·Mark T BanovetzDouglas G Wallace
Feb 14, 2021·Journal of Vestibular Research : Equilibrium & Orientation·E AnsonY Agrawal
Feb 24, 2020·Current Opinion in Neurobiology·Robert Gk Munn, Lisa M Giocomo

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