Head injury and brain tumours in adults: A case-control study in Rio de Janeiro, Brazil

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Gina Torres Rego MonteiroSérgio Koifman

Abstract

A hospital-based case-control study exploring the association between selected risk factors and head injury in adults, brain trauma included, was carried out in Greater Metropolitan Rio de Janeiro, Brazil. Cases included adults diagnosed with primary brain tumours (n = 231). Controls were matched for gender and age among in-patients hospitalized for various conditions unrelated to brain cancer (n = 261) identified in the same hospitals where cases were enrolled. Risk of having experienced head injury was more frequent among cases (46%) than controls (36%) (OR(adj) = 1.49; 95% CI = 1.03-2.15). A dose-response effect was observed according to the number of head injuries, and a statistically borderline association was observed for meningioma (OR(adj) = 1.63; 95% CI = 0.96-2.75). Although recall bias cannot be ruled out, our results suggest an association between prior head injury and the development of brain tumours in adults.

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Citations

Jun 22, 2010·Journal of Toxicology and Environmental Health. Part a·Guillermo Patricio Ortega JacomeSergio Koifman
Nov 29, 2015·Otolaryngologic Clinics of North America·Mahmoud AbbassyPablo F Recinos
Jan 28, 2015·Journal of Neurosurgery·Michelle A OwensDamon R Reed
Dec 18, 2015·Dose-response : a Publication of International Hormesis Society·Brant A Ulsh
Sep 15, 2016·Surgical Neurology International·Vineet TyagiDimitris G Placantonakis
Apr 22, 2008·Neurosurgery·Richard H SingletonL Dade Lunsford
Nov 27, 2009·The Journal of Head Trauma Rehabilitation·George W Rutherford, Renee C Wlodarczyk
Aug 22, 2018·International Journal of Molecular Sciences·Donata SimińskaIrena Baranowska-Bosiacka
Sep 15, 2021·International Journal of Cancer. Journal International Du Cancer·Sierra ChengRayjean J Hung

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Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.