Head-to-Head Comparison of Etanercept vs. Adalimumab in the Treatment of Ankylosing Spondylitis: An Open-Label Randomized Controlled Crossover Clinical Trial

Frontiers in Medicine
James Cheng-Chung WeiJin-Xian Huang

Abstract

Background: Anti-tumor necrosis factor biological agents had been proved to have a dramatic effect in ankylosing spondylitis (AS). We aimed to determine the efficacy and safety of crossover effects of adalimumab vs. etanercept in AS patients. Methods: A randomized, open-label crossover study was done in patients with active AS. Patients were randomized into two sequence groups, etanercept first (treatment arm) vs. adalimumab first (control arm) 8 weeks and then switched over for another 8 weeks. The primary endpoints were the difference of the Bath AS activity index and AS disease activity score (ASDAS)crp at week 16. Secondary endpoints were ASDASesr, ASAS20, and ASAS40 response rates and the proportion of patients achieving ASDAS inactive disease and low disease activity at weeks 8 and 16. Patient global assessment and preference was grading on a numerical scale. Results: A total of 21 patients were screened, and 19 of them were randomly allocated into the treatment arm (n = 9) and control arm (n = 9). At baseline, age, sex, Bath AS activity index, and ASDAS of both arms were comparable (p > 0.05). Both arms showed dramatic improvement, whereas no significance was observed between the changes of ASDAScrp (0.90 ± 1.39 vs. 1.24...Continue Reading

References

Nov 13, 2003·Arthritis and Rheumatism·John C DavisUNKNOWN Enbrel Ankylosing Spondylitis Study Group
Feb 5, 2005·Arthritis and Rheumatism·Désirée van der HeijdeUNKNOWN ASsessment in Ankylosing Spondylitis International Working Group
Dec 9, 2008·Annals of the Rheumatic Diseases·D van der HeijdeUNKNOWN Assessment of SpondyloArthritis international Society (ASAS)
Jul 25, 2015·BMC Musculoskeletal Disorders·Mariagrazia LorenzinRoberta Ramonda
May 30, 2017·Seminars in Arthritis and Rheumatism·Atul Deodhar, David Yu
Feb 9, 2018·The Journal of Rheumatology·Ennio LubranoAntonio Marchesoni
May 24, 2018·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Robert J MootsEduardo Mysler
Mar 23, 2019·Rheumatology International·José Miguel Senabre GallegoUNKNOWN AIRE-MB Group

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Clinical Trials Mentioned

NCT02489760

Software Mentioned

ASDASesr
Humira→Enbrel

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