Head to head comparison of N-terminal pro-B-type natriuretic peptide and B-type natriuretic peptide in patients with/without left ventricular systolic dysfunction

Clinical Biochemistry
M VanderheydenL Ide

Abstract

Human pro-B-type natriuretic peptide is cleaved into the active B-type natriuretic peptide (BNP) and the inactive fragment NT-proBNP. It is unclear if, similar to BNP, NT-proBNP can be used as a marker of impaired left ventricular (LV) ejection fraction (EF). This study evaluated the analytical performance of both assays to detect LV systolic dysfunction. In 72 patients with various degrees of left ventricular systolic dysfunction (LVSD), blood analysis for BNP and NT-proBNP was performed prior to cardiac catheterization, using a point-of-care analyzer (Biosite) and a fully automated laboratory analyzer (Roche-Elecsys), respectively. The within-run and between-run imprecision for BNP and NT-proBNP was calculated. Both markers were able to detect impaired LV EF with the largest area under the receiver-operating-characteristic curve for NT-proBNP (NT-proBNP: 0.851 (0.747-0.924); BNP: 0.803 (0.692-0.887) 95% confidence interval; P = 0.07). A significant correlation was observed between BNP and NT-proBNP (r = 0.9; P < 0.0001). Estimating the within-run imprecision, the coefficient of variance for BNP was 3.14% (n = 20, mean 316 ng/L) to 3.32% (n = 20, mean 820 ng/L) and for NT-proBNP 0.9% (n = 20, mean 4390.8 ng/L) to 1.4% (n = 20,...Continue Reading

References

Sep 19, 2000·Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology·R Latini, S Masson
Oct 24, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Serge MassonMaurizio Bevilacqua
Jun 12, 2003·Journal of the American College of Cardiology·Alan S MaiselUNKNOWN Breathing Not Properly Multinational Study Investigators
Aug 2, 2003·Critical Reviews in Clinical Laboratory Sciences·Anne-Marie LambeirIngrid De Meester
Aug 2, 2003·Lancet·James A de LemosMark H Drazner
Nov 26, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kiang-Teck J YeoAnthony W Butch
Feb 28, 2004·European Journal of Heart Failure·Marc VanderheydenMarc Goethals
Feb 28, 2004·European Journal of Heart Failure·R PfisterC A Schneider
Feb 28, 2004·European Journal of Heart Failure·Mark Richards, Richard W Troughton
Sep 25, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Lori J SokollChristiana Zingler
Dec 21, 2004·Journal of the American College of Cardiology·Marc VanderheydenJozef Bartunek
Aug 12, 2005·Mayo Clinic Proceedings·Paul M McKie, John C Burnett

❮ Previous
Next ❯

Citations

Dec 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Mustafa CerrahogluB Hayrettin Sirin
May 9, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Cecile GorissenMathie Leers
Sep 28, 2013·Journal of Perinatology : Official Journal of the California Perinatal Association·K FujiokaH Nakao
Jan 21, 2016·Expert Review of Molecular Diagnostics·Xi ZhangChamindie Punyadeera
Sep 24, 2009·Journal of Psychosomatic Research·Ranak B TrivediAndrew Sherwood
Dec 22, 2009·American Journal of Clinical Pathology·Pornpen SrisawasdiMartin H Kroll
Apr 2, 2008·International Journal of Cardiology·Johannes Steiner, Maya Guglin
Feb 26, 2008·American Heart Journal·Christopher RatnasamyPaolo Rusconi
Feb 25, 2009·Atherosclerosis·Emanuele BarbatoMassimo Volpe
Aug 23, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Aldo ClericoUNKNOWN Study Group on Cardiovascular Risk Biomarkers of the Italian Society of Clinical Biochemistry
Jun 7, 2008·Stroke; a Journal of Cerebral Circulation·Joan MontanerJosé Alvarez-Sabín
Mar 2, 2010·Yonsei Medical Journal·Shih-Hung TsaiShu-Meng Cheng
Sep 24, 2020·ESC Heart Failure·Katharina RapatzClaudia Stöllberger
Aug 9, 2018·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·G C M LinssenD J van Veldhuisen
Feb 26, 2021·Clinical Pharmacology and Therapeutics·Walter SchmittJörg Lippert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.