Head-to-head comparison of the diagnostic accuracies of BD Veritor™ System RSV and Quidel® Sofia® RSV FIA systems for respiratory syncytial virus (RSV) diagnosis

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Neena KanwarRangaraj Selvarangan

Abstract

Respiratory syncytial virus (RSV) is one of the most common causes of severe lower respiratory tract disease among infants and young children. BD Veritor™ System RSV (BD) and Quidel(®) Sofia(®) RSV FIA (QD) are the new generation lateral flow digital immunoassay (DIA) tests with an instrumented read for the qualitative detection of RSV viral antigens. To compare the diagnostic accuracies of BD and QD for RSV detection using fresh nasopharyngeal aspirates and nasopharyngeal swab specimens collected in universal transport media during 2013-2014 respiratory season. The two DIA tests were performed simultaneously on randomly selected specimens on a weekly basis during the RSV season until 200 fresh remnant specimens were enrolled. Real-time RT-PCR assay results were used to compare and evaluate the performance of both RSV DIA assays. Among 200 specimens tested, RSV real-time RT-PCR assay detected RSV in 104 samples, while QD detected 84 samples and BD detected 74 samples as positive. The overall sensitivity for detection of RSV in comparison to PCR was 71.15% (61.3-79.4) for BD and 80.77% (71.6-87.6) for QD system (P=0.36). The specificity was 100% (95.2-100) for both systems. The work flow analysis revealed that the overall specim...Continue Reading

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Citations

Feb 2, 2016·Diagnostic Microbiology and Infectious Disease·Pierre-Philippe Piché-RenaudChristian Renaud
Jul 29, 2015·The Journal of Infection·Nathan J BrendishTristan W Clark
Dec 22, 2017·Journal of Clinical Microbiology·Ferdaus HassanRangaraj Selvarangan
Jun 12, 2018·Expert Review of Molecular Diagnostics·Catherine A HoganJesse Papenburg
Dec 3, 2016·Clinical Microbiology Reviews·Cameron GriffithsDavid J Marchant
Dec 19, 2017·Expert Review of Molecular Diagnostics·Kerri BasileDominic E Dwyer
Dec 14, 2018·Clinical Microbiology Reviews·Carmen L CharltonSteven J Drews
Oct 12, 2016·Microbiology Spectrum·Richard L Hodinka
Oct 9, 2021·Advanced Materials·Zhaowei ZhangUtkan Demirci

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