Head-to-Head Evaluation of 18F-FES and 18F-FDG PET/CT in Metastatic Invasive Lobular Breast Cancer.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Gary A UlanerAudrey Mauguen

Abstract

Invasive lobular carcinoma (ILC) demonstrates lower conspicuity on 18F-FDG PET than the more common invasive ductal carcinoma. Other molecular imaging methods may be needed for evaluation of this malignancy. As ILC is nearly always (95%) estrogen receptor (ER)-positive, ER-targeting PET tracers such as 16α-18F-fluoroestradiol (18F-FES) may have value. We reviewed prospective trials at Memorial Sloan Kettering Cancer Center using 18F-FES PET/CT to evaluate metastatic ILC patients with synchronous 18F-FDG and 18F-FES PET/CT imaging, which allowed a head-to-head comparison of these 2 PET tracers. Methods: Six prospective clinical trials using 18F-FES PET/CT in patients with metastatic breast cancer were performed at Memorial Sloan Kettering Cancer Center from 2008 to 2019. These trials included 92 patients, of whom 14 (15%) were of ILC histology. Seven of 14 patients with ILC had 18F-FDG PET/CT performed within 5 wk of the research 18F-FES PET/CT and no intervening change in management. For these 7 patients, the 18F-FES and 18F-FDG PET/CT studies were analyzed to determine the total number of tracer-avid lesions, organ systems of involvement, and SUVmax of each organ system for both tracers. Results: In the 7 comparable pairs of s...Continue Reading

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Dec 19, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Richard L WahlJohn Sunderland
May 16, 2021·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jorianne BoersCarolina P Schröder
Sep 22, 2021·Journal of Medical Imaging and Radiation Oncology·Tetsuya TsujikawaHidehiko Okazawa

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