Heading in soccer increases serum neurofilament light protein and SCAT3 symptom metrics

BMJ Open Sport & Exercise Medicine
Colin WallacePaul van Donkelaar

Abstract

To determine the effect of heading a soccer ball on serum neurofilament light (NF-L) protein, plasma tau protein and symptom metrics including total number of symptoms reported and symptom severity scores on the Standardized Concussion Assessment Tool- 3rd edition (SCAT3). Eleven male collegiate soccer players were recruited to take part in three experimental conditions including heading, sham and control conditions. Participants were required to perform 40 headers in 20 min in the heading condition, and control 40 soccer balls directed at them with their hands, chest or thigh in the sham condition. No ball contact was made during the control condition. Blood sampling and SCAT3 symptom assessments were completed prior to and 1 hour following conditions. A subset of participants returned 3 weeks following the heading condition for blood sampling. NF-L was elevated at 1 hour (p=0.004) and 1 month (p=0.04) following the heading condition, and at 1 hour (p=0.02) following the control condition. Tau levels remained unchanged following all conditions. The total number of symptoms (TS) and symptom severity (SS) scores from the SCAT3 were both elevated following the heading condition (p=0.01 and p=0.03, respectively). Both TS and SS de...Continue Reading

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Citations

Nov 14, 2018·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Amit SinglaR Shane Tubbs
Jan 23, 2020·Brain Sciences·Kate L LambertsenHelle H Nielsen
Dec 11, 2019·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Matthias BesseDavid Zilles
Mar 4, 2020·Neurosurgery·John K YueMitchel S Berger
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Jul 30, 2021·Journal of Biomechanics·Tanner M FilbenJoel D Stitzel

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Methods Mentioned

BETA
blood draw
ELISA

Software Mentioned

GraphPad Prism
SPSS

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