Healing of acetic acid-induced gastric ulcer and gastric mucosal PGI2 level in rats

Digestive Diseases and Sciences
M UchidaO Irino

Abstract

The present study was designed to investigate the changes in gastric mucosal PGI2 level accompanying the healing of acetic acid-induced gastric ulcers in rats. The ulcers, which were observed with an endoscope, were found to undergo periods of decrease, healing and exacerbation during the rat's lifetime. The phases were categorized as follows: (1) the reduction period (days 3-50 after ulcer induction, corresponding to 7-14 weeks of age), (2) healing period (days 35-150 after ulcer induction, corresponding to 12-29 weeks of age), (3) first exacerbation period (days 35-231 after ulcer induction, corresponding to 12-40 weeks of age), (4) inactive period (days 231-365 after ulcer induction, corresponding to 40-60 weeks of age), and (5) second exacerbation period (days 365-550 after ulcer induction, corresponding to 60-86 weeks of age). In normal rats, the level of gastric mucosal PGI2 gradually increased with aging between 7 and 20 weeks, then decreased up to 40 weeks. The PGI2 level in the 60-week-old rat did not differ from that in the 40-week-old rat. The PGI2 level was the lowest in the 86-week-old rat. In ulcer-bearing rats, the PGI2 level showed the same pattern of change as that in normal rats, but the level was higher. The ...Continue Reading

References

Feb 1, 1981·Prostaglandins and Medicine·R V PanganamalaA J Merola

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Citations

Jan 1, 1992·Agents and Actions·D M McCafferty, I J Zeitlin
May 1, 1994·Digestive Diseases and Sciences·A G PenneyP E O'Brien
Jul 5, 2003·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Susumu Okabe, Kikuko Amagase
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Jan 1, 1991·Alimentary Pharmacology & Therapeutics·A TarnawskiW J Krause

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