Healing of osteochondral transplants--animal experiment studies using a sheep model

Zeitschrift für Orthopädie und ihre Grenzgebiete
C H SiebertC Niedhart

Abstract

Autologous grafting has developed into one of the preferred methods of treatment for focal osteochondral lesions, although basic research on this topic remains sparse. In an animal study, questions regarding the healing of such osteochondral transplants are clarified. An autologous osteochondral transplantation was performed on the ovine knee using the standard operative protocol. Two groups, consisting of 10 sheep each, were evaluated after 3 and 6 months, respectively. During the clinical evaluation of the specimens, neither osteophytes nor synovial changes were observed. The consistency of the cartilaginous tissue began to reach a level equivalent to the surrounding tissue only after 6 months. Macroscopically, the superficial border of the transplanted osteochondral plug could easily be outlined at both time points. Radiographically, a solid osteointegration of the graft could already be documented at 3 months. In contrast, integration of the chondral surface of the OAT was not seen macro- or microscopically at any point in time. A firm physical interdigitation of the reconstructed joint surface could not be demonstrated. The lack of integration of the cartilaginous portion of the transplanted plugs into the reconstructed jo...Continue Reading

Citations

Dec 20, 2005·Archives of Orthopaedic and Trauma Surgery·Christian H SiebertChristopher Niedhart
Dec 8, 2007·Archives of Orthopaedic and Trauma Surgery·Klaus BaumbachNorbert M Meenen
Mar 2, 2011·Archives of Orthopaedic and Trauma Surgery·Carsten O TibeskuS Fuchs-Winkelmann
Oct 12, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C O TibeskuS Fuchs
Mar 3, 2006·Cell and Tissue Banking·Sally R FrenkelKate G Truncale

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