Healing properties of allograft from alendronate-treated animal in lumbar spine interbody cage fusion

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Qingyun XueCody Bünger

Abstract

This study investigated the healing potential of allograft from bisphosphonate-treated animals in anterior lumbar spine interbody fusion. Three levels of anterior lumbar interbody fusion with Brantigan cages were performed in two groups of five landrace pigs. Empty Brantigan cages or cages filled with either autograft or allograft were located randomly at different levels. The allograft materials for the treatment group were taken from the pigs that had been fed with alendronate, 10 mg daily for 3 months. The histological fusion rate was 2/5 in alendronate-treated allograft and 3/5 in non-treated allograft. The mean bone volume was 39% and 37.2% in alendronate-treated or non-treated allograft (NS), respectively. No statistical difference was found between the same grafted cage comparing two groups. The histological fusion rate was 7/10 in all autograft cage levels and 5/10 in combined allograft cage levels. No fusion was found at all in empty cage levels. With the numbers available, no statistically significant difference was found in histological fusion between autograft and allograft applications. There was a significant difference of mean bone volume between autograft (49.2%) and empty cage (27.5%) (P<0.01). In conclusion, t...Continue Reading

References

May 1, 1988·The Journal of Bone and Joint Surgery. British Volume·C A DoddD Thomas
Mar 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J S Wang, P Aspenberg
Aug 1, 1996·Clinical Orthopaedics and Related Research·E D ArringtonN A Davino
Jun 3, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J LiH Norimatsu
Jun 29, 1999·Clinical Pharmacokinetics·A G PorrasB J Gertz
Dec 28, 1999·Clinical Orthopaedics and Related Research·D P GroganL I Pugh
Feb 29, 2000·Clinical Orthopaedics and Related Research·D M Ehrler, A R Vaccaro
Apr 4, 2002·Acta Orthopaedica Scandinavica·Per Aspenberg, Jörgen Astrand
Oct 18, 2002·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Haisheng LiCody Bünger

❮ Previous
Next ❯

Citations

Jan 17, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Michael PutzierAxel Pruss
Jun 1, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Hui HuangXiaoxing Jiang
Sep 5, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Samuel K ChoYongjung J Kim
Jun 5, 2012·The Spine Journal : Official Journal of the North American Spine Society·Brandon P HirschJoseph M Lane
Aug 23, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Haisheng LiCody Bünger
Sep 3, 2017·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Qirui DingLipeng Yu
Nov 15, 2005·Spine·Russel C HuangJoseph M Lane
Feb 28, 2009·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Shyh Ming KuoShwu Jen Chang
Aug 26, 2020·Tissue Engineering. Part a·Marwa Y ShaheenHamdan S Alghamdi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.