Healing Properties of Some Indian Medicinal Plants against Indomethacin-Induced Gastric Ulceration of Rats

Journal of Clinical Biochemistry and Nutrition
Sayanti BhattacharyaSandip K Bandyopadhyay

Abstract

The healing activity of the ethanol extracts of Piper betel, Emblica officinalis, Terminalia bellerica, and Terminalia chebula against the indomethacin-induced stomach ulceration has been studied and compared with that of misoprostol. Compared to autohealing, all the drugs accelerated the healing process, albeit to different extents. The relative healing activities of the extracts was P. betel>E. officinalis>T. bellerica~T. chebula, that correlated well with their in vivo antioxidant and mucin augmenting activities. The excellent healing activity of the extracts of P. betel and E. officinalis indicated a major role of mucin protection and regeneration in the healing of nonsteroidal anti-inflammatory drugs mediated stomach ulceration.

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Citations

Aug 1, 2011·Asian Pacific Journal of Tropical Biomedicine·Rao G TirupathiA S Sreedhar
Dec 29, 2013·Journal of Agricultural and Food Chemistry·Baoru Yang, Pengzhan Liu
Feb 2, 2008·BMC Complementary and Alternative Medicine·Debashish BanerjeeSubrata Chattopadhyay
Jun 6, 2014·BioMed Research International·Paulo Humberto M NunesFernanda Regina C Almeida
Aug 28, 2014·Chinese Journal of Integrative Medicine·Farhan FazalManjeshwar Shrinath Baliga
Jun 25, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Hock Eng KhooAmin Ismail
Mar 13, 2012·International Journal of Molecular Sciences·Suhailah Wasman QaderSalehhuddin Hamdan
Mar 30, 2018·Mini Reviews in Medicinal Chemistry·Sobhi M GomhaIslam K Matar
Mar 25, 2019·BioMed Research International·Jung Uoon ParkYoung Ik Lee

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