Healing rate and autoimmune safety of full-thickness wounds treated with fish skin acellular dermal matrix versus porcine small-intestine submucosa: a noninferiority study

The International Journal of Lower Extremity Wounds
Baldur Tumi BaldurssonSigrún Helga Lund

Abstract

A novel product, the fish skin acellular dermal matrix (ADM) has recently been introduced into the family of biological materials for the treatment of wounds. Hitherto, these products have been produced from the organs of livestock. A noninferiority test was used to compare the effect of fish skin ADM against porcine small-intestine submucosa extracellular matrix in the healing of 162 full-thickness 4-mm wounds on the forearm of 81 volunteers. The fish skin product was noninferior at the primary end point, healing at 28 days. Furthermore, the wounds treated with fish skin acellular matrix healed significantly faster. These results might give the fish skin ADM an advantage because of its environmental neutrality when compared with livestock-derived products. The study results on these acute full-thickness wounds might apply for diabetic foot ulcers and other chronic full-thickness wounds, and the shorter healing time for the fish skin-treated group could influence treatment decisions. To test the autoimmune reactivity of the fish skin, the participants were tested with the following ELISA (enzyme-linked immunosorbent assay) tests: RF, ANA, ENA, anti ds-DNA, ANCA, anti-CCP, and anticollagen I and II. These showed no reactivity. T...Continue Reading

References

Jan 1, 1991·Archives of Dermatological Research·F TrautingerE J Menzel
Nov 1, 1991·Archives of Dermatology·A J NemethV Falanga
Dec 1, 1989·Journal of the American Academy of Dermatology·G CharriereD J Hartmann
Nov 13, 1989·Journal of Immunological Methods·K FujiiY Nagai
May 1, 1972·Journal of Biochemistry·D Fujimoto
Jan 1, 1996·The Journal of Surgical Research·K M ClarkeS L Voytik
Nov 17, 2001·Journal of the American Academy of Dermatology·M A Cohen, W H Eaglstein
Apr 24, 2003·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·M DysonP Wilson
Sep 11, 2003·Journal of Wound Care·M S AgrenJ Rygaard
Apr 28, 2004·Psychoneuroendocrinology·Marcel EbrechtJohn Weinman
Sep 24, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·A K LynnW Bonfield
May 12, 2005·Journal of Vascular Surgery·Eliot N MostowUNKNOWN OASIS Venus Ulcer Study Group
Sep 21, 2005·Archives of Dermatology·Leslie J ChristensonClark C Otley
May 13, 2008·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jodi C McDanielWendy Blakely
Sep 26, 2009·Clinics in Podiatric Medicine and Surgery·Kevin G CornwellKenneth S James
Sep 22, 2010·Journal of General Internal Medicine·Esteban Walker, Amy S Nowacki
Mar 3, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jodi C McDanielAnna Nicolaou
Jan 27, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Alan D Widgerow
Jul 25, 2012·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·S J KoppelmanS L Taylor
Sep 2, 2014·Biochemical Pharmacology·Sylvie Legrand-PoelsJacques Piette
Oct 8, 2014·Plastic and Reconstructive Surgery. Global Open·David M AdelmanCharles E Butler

❮ Previous
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Citations

Nov 26, 2003·Clinics in Podiatric Medicine and Surgery·Robert G Frykberg
Jul 6, 2006·European Urology·Gerhard FeilKarl-Dietrich Sievert
Aug 18, 2016·Journal of Cutaneous Medicine and Surgery·Mathew N Nicholas, Jensen Yeung
Oct 14, 2017·Regenerative Biomaterials·Lin-Cui DaHui-Qi Xie
Oct 20, 2018·The International Journal of Lower Extremity Wounds·Skuli MagnussonGudmundur Fertram Sigurjonsson
Sep 13, 2019·Journal of Wound Care·Nathalie BadoisIsabelle Fromantin
Dec 12, 2019·Journal of Tissue Engineering and Regenerative Medicine·Aristotelis KotronoulasÓttar Rolfsson
Aug 28, 2018·Gefässchirurgie : Zeitschrift für vaskuläre und endovaskuläre Chirurgie : Organ der Deutschen und der Österreichischen Gesellschaft für Gefässchirurgie unter Mitarbeit der Schweizerischen Gesellschaft für Gefässchirurgie·B DorweilerH Diener
Sep 23, 2018·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·N KirstenH Diener
Jul 29, 2017·Hernia : the Journal of Hernias and Abdominal Wall Surgery·F LesageJ Deprest
Sep 12, 2019·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Robert S KirsnerJohn C Lantis
Jul 30, 2019·Stem Cells International·Amtoj KaurSujata Mohanty
Jan 7, 2021·Marine Biotechnology·Matheus Almeida CruzAna Claudia Muniz Rennó
Feb 10, 2021·International Journal of Molecular Sciences·Randolph StoneRobert J Christy
Mar 13, 2021·Xenotransplantation·Héctor Capella-Monsonís, Dimitrios I Zeugolis
Jun 3, 2021·Bioengineering·Shomita S Mathew-SteinerChandan K Sen
Sep 22, 2021·The Journal of the American Academy of Orthopaedic Surgeons·Benjamin C TaylorMark Wells
Nov 26, 2021·Experimental Dermatology·Anna-Lena SeveringEwa Klara Stürmer

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Methods Mentioned

BETA
biopsy
ELISA

Software Mentioned

EpiCalc
R

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