Health and economic benefits of public financing of epilepsy treatment in India: An agent-based simulation model

Epilepsia
Itamar MegiddoRamanan Laxminarayan

Abstract

An estimated 6-10 million people in India live with active epilepsy, and less than half are treated. We analyze the health and economic benefits of three scenarios of publicly financed national epilepsy programs that provide: (1) first-line antiepilepsy drugs (AEDs), (2) first- and second-line AEDs, and (3) first- and second-line AEDs and surgery. We model the prevalence and distribution of epilepsy in India using IndiaSim, an agent-based, simulation model of the Indian population. Agents in the model are disease-free or in one of three disease states: untreated with seizures, treated with seizures, and treated without seizures. Outcome measures include the proportion of the population that has epilepsy and is untreated, disability-adjusted life years (DALYs) averted, and cost per DALY averted. Economic benefit measures estimated include out-of-pocket (OOP) expenditure averted and money-metric value of insurance. All three scenarios represent a cost-effective use of resources and would avert 800,000-1 million DALYs per year in India relative to the current scenario. However, especially in poor regions and populations, scenario 1 (which publicly finances only first-line therapy) does not decrease the OOP expenditure or provide f...Continue Reading

References

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Citations

Dec 6, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hong-Jian ZhangZhe-Shan Quan
Sep 9, 2018·The European Journal of Neuroscience·Xiaoya FanAntoine Nonclercq
Feb 13, 2019·International Journal of Molecular Sciences·Shaip Krasniqi, Armond Daci
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May 1, 2020·NPJ Digital Medicine·Khaled SaabChristopher Lee-Messer
Oct 20, 2020·Expert Review of Pharmacoeconomics & Outcomes Research·Isabel Barrachina-MartinezFrancisco Reyes-Santias
Sep 17, 2020·Neurology·Emma FosterZanfina Ademi
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Edilene Gadelha de OliveiraRuy Carlos Ruver Beck
Dec 8, 2020·Frontiers in Neuroscience·Guokai ZhangWenliang Che
Feb 17, 2021·The International Journal of Health Planning and Management·Reda Lebcir, Rifat Atun
Feb 19, 2021·NPJ Digital Medicine·Khaled SaabChristopher Lee-Messer
Jul 20, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Nasiara KarimAhmed Al-Harrasi
Oct 8, 2021·Metabolic Brain Disease·Zenat Fatima KhattakRizwan Ul Haq

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Software Mentioned

R
IndiaSim

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