Health disparities among adult patients with a phenotypic diagnosis of familial hypercholesterolemia in the CASCADE-FH™ patient registry

Atherosclerosis
Stephen M AmrockZahid S Ahmad

Abstract

Most familial hypercholesterolemia (FH) patients remain undertreated, and it is unclear what role health disparities may play for FH patients in the US. We sought to describe sex and racial/ethnic disparities in a national registry of US FH patients. We analyzed data from 3167 adults enrolled in the CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia (CASCADE-FH) registry. Logistic regression was used to evaluate for disparities in LDL-C goals and statin use, with adjustments for covariates including age, cardiovascular risk factors, and statin intolerance. In adjusted analyses, women were less likely than men to achieve treated LDL-C of <100 mg/dL (OR 0.68, 95% CI, 0.57-0.82) or ≥50% reduction from pretreatment LDL-C (OR 0.79, 95% CI, 0.65-0.96). Women were less likely than men to receive statin therapy (OR, 0.60, 95% CI, 0.50-0.73) and less likely to receive a high-intensity statin (OR, 0.60, 95% CI, 0.49-0.72). LDL-C goal achievement also varied by race/ethnicity: compared with whites, Asians and blacks were less likely to achieve LDL-C levels <100 mg/dL (Asians, OR, 0.47, 95% CI, 0.24-0.94; blacks, OR, 0.49, 95% CI, 0.32-0.74) or ≥50% reduction from pretreatment LDL-C (Asians, OR 0.56, 95% CI, 0.3...Continue Reading

Citations

Jan 31, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Graham H Bevan, Khendi T White Solaru
Sep 15, 2018·Frontiers in Cardiovascular Medicine·Leo UngarAilin Barseghian
Jan 25, 2020·Nature Reviews. Cardiology·Gerald F WattsKausik K Ray
Aug 21, 2020·Current Atherosclerosis Reports·Sujana BallaFatima Rodriguez
Sep 3, 2020·Heart, Lung & Circulation·Jing PangUNKNOWN members of the FH Australasia Network Registry
Jun 2, 2021·The Journal of Clinical Investigation·Giorgio SirugoScott M Williams
Aug 26, 2021·Journal of the American Heart Association·Anandita AgarwalaAnne C Goldberg

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