Health Economics Tools and Precision Medicine: Opportunities and Challenges.

Forum for Health Economics & Policy
D L VeenstraScott D Ramsey

Abstract

Precision medicine - individualizing care for patients and addressing variations in treatment response - is likely to be important in improving the nation's health in a cost-effective manner. Despite this promise, widespread use of precision medicine, specifically genomic markers, in clinical care has been limited in practice to date. Lack of evidence, clear evidence thresholds, and reimbursement have been cited as major barriers. Health economics frameworks and tools can elucidate the effects of legal, regulatory, and reimbursement policies on the use of precision medicine while guiding research investments to enhance the appropriate use of precision medicine. Despite the capacity of economics to enhance the clinical and human impact of precision medicine, application of health economics to precision medicine has been limited - in part because precision medicine is a relatively new field - but also because precision medicine is complex, both in terms of its applications and implications throughout medicine and the healthcare system. The goals of this review are several-fold: (1) provide an overview of precision medicine and key policy challenges for the field; (2) explain the potential utility of economics methods in addressin...Continue Reading

References

Jul 24, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Naomi E JonesDaren K Heyland
Oct 11, 2007·JAMA : the Journal of the American Medical Association·Wylie Burke, Bruce M Psaty
Sep 5, 2008·PharmacoEconomics·Mark Sculpher
Nov 4, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Scott D GrosseKatherine Payne
Nov 17, 2009·Nature Genetics·Sarah B NgMichael J Bamshad
Dec 5, 2009·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Anirban Basu
Mar 2, 2010·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Bas Groot KoerkampM G Myriam Hunink
Apr 24, 2010·The Lancet Oncology·Mary V RellingWilliam E Evans
May 4, 2010·Lancet·Euan A AshleyRuss B Altman
Jun 29, 2010·Journal of the American College of Cardiology·Geoffrey S Ginsburg, Deepak Voora
Aug 14, 2010·Human Molecular Genetics·Jamie K Teer, James C Mullikin
Sep 3, 2010·Genetics in Medicine : Official Journal of the American College of Medical Genetics·David L VeenstraWylie Burke
Oct 27, 2010·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Bas Groot KoerkampM G Myriam Hunink
Jan 29, 2011·Clinical Pharmacology and Therapeutics·M V Relling, T E Klein
Feb 11, 2011·Nature·Elaine R Mardis
Feb 11, 2011·Nature·Eric D GreenUNKNOWN National Human Genome Research Institute
Oct 20, 2011·Statistics in Biosciences·Anirban Basu
Jan 24, 2012·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Aukje van GestelJohan Severens
Jan 12, 2013·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Teri A ManolioGeoffrey S Ginsburg
May 3, 2013·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Josh J CarlsonDavid L Veenstra
Aug 7, 2013·JAMA : the Journal of the American Medical Association·Bridget M Kuehn
Sep 27, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Adrian Towse, Louis P Garrison
Jan 24, 2015·Genome Medicine·Jennifer S Blumenthal-BarbyPeter A Ubel
Jan 31, 2015·The New England Journal of Medicine·Francis S Collins, Harold Varmus
Mar 11, 2015·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Dean A RegierDavid Veenstra
May 1, 2015·JAMA : the Journal of the American Medical Association·Euan A Ashley
Jun 4, 2015·JAMA : the Journal of the American Medical Association·Muin J Khoury, James P Evans
Jun 6, 2015·Mayo Clinic Proceedings·Amy L KaufmanPeter H O'Donnell
Aug 4, 2015·Journal of Managed Care & Specialty Pharmacy·William J CanestaroDavid L Veenstra
Oct 16, 2015·Nature·Samuel J Aronson, Heidi L Rehm
Oct 28, 2015·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Anirban BasuDavid L Veenstra
Mar 30, 2016·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Maria KoufopoulouLavanya Diwakar
Jun 3, 2016·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Deborah A MarshallKathryn A Phillips
Sep 17, 2016·Science·Jeff Shrager
Feb 23, 2017·Breast Cancer Research and Treatment·Tracy A LieuJeanne S Mandelblatt
Mar 18, 2017·Science·A D SternA Chandra
May 30, 2017·Annals of Internal Medicine·Julia Wynn, Wendy K Chung
Sep 22, 2017·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Zhuo ChenMuin J Khoury
Oct 17, 2017·Clinical Pharmacology and Therapeutics·Ariel D SternAmitabh Chandra
Oct 27, 2017·International Journal of Technology Assessment in Health Care·James D ChambersKathryn A Phillips
Dec 2, 2017·Science·Rebecca Eisenberg, Harold Varmus
Jan 9, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Young ChandlerJeanne S Mandelblatt
Jan 20, 2018·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Tara A LavellePeter J Neumann
Feb 16, 2018·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Katharina SchwarzeSarah Wordsworth

❮ Previous
Next ❯

Citations

Nov 2, 2020·Life Sciences, Society and Policy·M Walid QoronflehSaid Ismail
Aug 28, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F MoseleF André
Apr 30, 2021·Expert Review of Pharmacoeconomics & Outcomes Research·Martijn SimonsValesca Retèl
May 2, 2021·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T S Bekaii-SaabN Normanno

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Bulletin of the American College of Surgeons
William D Strinden
The Recorder of the Columbia Medical Society of Richland County, S. C
E E IRONS
The Journal of the Kansas Medical Society
F F WEHRENBERG
World Medical Journal
J R GOSSET, M CHASSERANT
Wisconsin Medical Journal
R Andreano
© 2021 Meta ULC. All rights reserved