Health education through analogies: preparation of a community for clinical trials of a vaccine against hookworm in an endemic area of Brazil.

PLoS Neglected Tropical Diseases
Maria Flávia GazzinelliDavid J Diemert

Abstract

Obtaining informed consent for clinical trials is especially challenging when working in rural, resource-limited areas, where there are often high levels of illiteracy and lack of experience with clinical research. Such an area, a remote field site in the northeastern part of the state of Minas Gerais, Brazil, is currently being prepared for clinical trials of experimental hookworm vaccines. This study was conducted to assess whether special educational tools can be developed to increase the knowledge and comprehension of potential clinical trial participants and thereby enable them to make truly informed decisions to participate in such research. An informational video was produced to explain the work of the research team and the first planned hookworm vaccine trial, using a pedagogical method based on analogies. Seventy-two adults living in a rural community of Minas Gerais were administered a structured questionnaire that assessed their knowledge of hookworm, of research and of the planned hookworm vaccine trial, as well as their attitudes and perceptions about the researchers and participation in future vaccine trials. The questionnaire was administered before being shown the educational video and two months after and the r...Continue Reading

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Citations

Nov 8, 2014·BMC Public Health·Lucas LobatoMaria Flávia Gazzinelli
Aug 2, 2011·Journal of Community Health·Sherrie Flynt WallingtonJeanne Mandelblatt
Jan 5, 2011·Immunological Reviews·Jeffrey M BethonyPeter J Hotez
Jul 2, 2019·International Journal of Nursing Practice·Emmanuel Dayao Paragas, Teresita I Barcelo
Aug 8, 2014·Cadernos de saúde pública·Lucas LobatoAmanda Nathale Soares
Nov 16, 2021·Journal of Health Communication·Grace M Hildenbrand

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