PMID: 698135Aug 1, 1978Paper

Health effects of acrylonitrile in acrylic fibre factories

British Journal of Industrial Medicine
H SakuraiH Matsumura

Abstract

The relationship between the degree of exposure and biological effects of acrylonitrile (AN) was studied in 102 workers whose exposure period exceeded five years, and in 62 matched controls, all of whom had been randomly sampled from six acrylic fibre factories in Japan. The six factories were classified into three groups on the basis of AN concentration at workplaces. The most highly exposed group of subjects showed an eight-hour average AN concentration of 4-2 ppm by personal sampling, a mean urinary AN concentration of 360 microgram/1 and a mean urinary thiocyanate concentration of 11-4 mg/1. Medical examination, including the indocyanine green excretion test and multiple clinical chemistry determinations, failed to detect any health effect attributable to AN. Slight liver damage may possibly occur in more highly exposed workers. Urinary AN and thiocyanate determinations may provide more accurate estimates of low-grade exposure (less than 5 ppm).

References

Jul 1, 1977·American Journal of Public Health·W J Curran
Jul 1, 1974·Archives of Dermatology·G F RadimerA B Ackerman
Aug 26, 1967·Nature·H Kuno, H K Kihara
Dec 31, 1969·Annals of the New York Academy of Sciences·G Wennström
Aug 25, 1950·Deutsche medizinische Wochenschrift·H LORZ

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Citations

Aug 1, 1987·Archives of Toxicology·G MüllerK Norpoth
Dec 14, 2004·International Archives of Occupational and Environmental Health·M Imbriani, S Ghittori
Jan 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N J van Sittert, G de Jong
Feb 1, 1984·British Journal of Industrial Medicine·M Døssing, L Ranek
Dec 1, 1987·British Journal of Industrial Medicine·M JakubowskiJ Kopecký
Sep 3, 2008·Risk Analysis : an Official Publication of the Society for Risk Analysis·C R KirmanR Deskin
Aug 7, 1998·Regulatory Toxicology and Pharmacology : RTP·J WhysnerG M Williams
Jun 18, 1999·Human & Experimental Toxicology·M T BrondeauO Schneider
Jan 1, 1982·American Journal of Industrial Medicine·D HouthuijsK Biersteker
Nov 8, 2005·Human & Experimental Toxicology·L T Haber, J Patterson

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