Health implications of high dietary omega-6 polyunsaturated Fatty acids.

Journal of Nutrition and Metabolism
E PattersonC Stanton

Abstract

Omega-6 (n-6) polyunsaturated fatty acids (PUFA) (e.g., arachidonic acid (AA)) and omega-3 (n-3) PUFA (e.g., eicosapentaenoic acid (EPA)) are precursors to potent lipid mediator signalling molecules, termed "eicosanoids," which have important roles in the regulation of inflammation. In general, eicosanoids derived from n-6 PUFA are proinflammatory while eicosanoids derived from n-3 PUFA are anti-inflammatory. Dietary changes over the past few decades in the intake of n-6 and n-3 PUFA show striking increases in the (n-6) to (n-3) ratio (~15 : 1), which are associated with greater metabolism of the n-6 PUFA compared with n-3 PUFA. Coinciding with this increase in the ratio of (n-6) : (n-3) PUFA are increases in chronic inflammatory diseases such as nonalcoholic fatty liver disease (NAFLD), cardiovascular disease, obesity, inflammatory bowel disease (IBD), rheumatoid arthritis, and Alzheimer's disease (AD). By increasing the ratio of (n-3) : (n-6) PUFA in the Western diet, reductions may be achieved in the incidence of these chronic inflammatory diseases.

References

Jan 1, 1985·Annual Review of Nutrition·A Sevanian, P Hochstein
Dec 12, 1980·JAMA : the Journal of the American Medical Association·M A Shampo, R A Kyle
Dec 1, 1980·The American Journal of Clinical Nutrition·H O BangH M Sinclair
Jun 13, 1996·The New England Journal of Medicine·A BelluzziM Miglioli
May 8, 1999·The American Journal of Clinical Nutrition·F B HuW C Willett
Jun 8, 1999·The Journal of Clinical Investigation·S KerstenW Wahli
Jul 9, 1999·Biochimica Et Biophysica Acta·J PrescottG H Tomkin
Jan 8, 2000·The Journal of Biological Chemistry·C L CurtisB Caterson
Mar 29, 2001·Nature Structural Biology
Jul 4, 2001·The Journal of Clinical Investigation·S L TilleyB H Koller
Jul 4, 2001·The Journal of Clinical Investigation·S Narumiya, G A FitzGerald
Dec 1, 2001·Science·A ChawlaD J Mangelsdorf
Dec 14, 2002·Journal of the American College of Nutrition·Artemis P Simopoulos
Dec 19, 2002·Journal of Medicinal Food·Claude L Hughes, Tilak R Dhiman
Jan 23, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Rodolfo R Brenner
Feb 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Dilprit BaggaSrinivasa T Reddy
Apr 17, 2003·The Journal of Clinical Investigation·Roy J Soberman, Peter Christmas
Jun 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Emilia IpIsabelle Leclercq
Jul 4, 2003·European Journal of Gastroenterology & Hepatology·Kevin D Cashman, F Shanahan
Aug 15, 2003·The Journal of Biological Chemistry·Anjali PawarDonald B Jump
Nov 1, 2003·Thrombosis Research·Tomomi IdeGarret A FitzGerald
Feb 14, 2004·Journal of the American College of Nutrition·Yan ZhaoLinda H Chen
May 4, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Emilia IpIsabelle Leclercq

❮ Previous
Next ❯

Citations

Aug 21, 2013·Reviews in Endocrine & Metabolic Disorders·Senthil Arun Kumar, Lindsay Brown
Jan 25, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·K E WoodB S Muhlhausler
Apr 3, 2014·Cancer Immunology, Immunotherapy : CII·Sheng XiaLing Qi
Aug 27, 2014·The Veterinary Clinics of North America. Exotic Animal Practice·Johanna Mejia-Fava, Carmen M H Colitz
Dec 3, 2014·Molecular and Cellular Endocrinology·B S DunbarR J Deckelbaum
Apr 23, 2013·Expert Opinion on Therapeutic Targets·Akiko EguchiAriel E Feldstein
Sep 24, 2015·International Journal of Molecular Sciences·Hanne K MaehreKarl-Erik Eilertsen
Jan 9, 2016·Journal of Agricultural and Food Chemistry·Cesare CastelliniGenciana Terova
Mar 19, 2013·Journal of the Chinese Medical Association : JCMA·Chin-Wen Chi
Sep 25, 2012·Progress in Lipid Research·Leanne Hodson, Barbara A Fielding
Jan 8, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·P G PanagosS Sen
Sep 5, 2015·The Journal of Nutritional Biochemistry·Justine MarchixPhilippe Legrand
Oct 8, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Woon-Puay KohJian-Min Yuan
Jul 1, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tomokazu IshitobiKazuaki Chayama
Apr 2, 2015·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·K FeketeT Decsi
Feb 11, 2015·Leukemia Research·Artur JurczyszynAleksander B Skotnicki
Mar 15, 2015·Brain, Behavior, and Immunity·Uté Vollmer-ConnaGordon Parker
Mar 12, 2015·Pediatric Research·Jonathan Y BernardUNKNOWN EDEN Mother-Child Cohort Study Group
May 3, 2015·Pharmacological Reports : PR·Joanna Gdula-ArgasińskaTadeusz Librowski
Apr 22, 2016·Nutritional Neuroscience·Jimena Verónica LavanderaMarcela Aída González
Jan 8, 2013·The International Journal of Biochemistry & Cell Biology·J Jasper DeuringC Janneke van der Woude
Nov 26, 2015·Journal of the Science of Food and Agriculture·Jelena KruljMarija Bodroža Solarov
Sep 23, 2016·Critical Reviews in Biotechnology·Ana Maria de Oliveira FincoCarlos Ricardo Soccol
Jul 19, 2013·Annual Review of Nutrition·E Scorletti, C D Byrne
Oct 26, 2016·Journal of Photochemistry and Photobiology. B, Biology·Renata Ottes VasconcelosGilma Santos Trindade
Oct 11, 2016·Journal of Dairy Science·Tom F O'CallaghanCatherine Stanton
Oct 11, 2016·Journal of Agricultural and Food Chemistry·Amy Botta, Sanjoy Ghosh
Dec 16, 2016·International Journal of Molecular Sciences·Salvatore PettaFerruccio Bonino

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.