Health-protective and adverse effects of the apolipoprotein E epsilon2 allele in older men

Journal of the American Geriatrics Society
Alexander KulminskiAnatoli I Yashin

Abstract

To reexamine a health-protective role of the common apolipoprotein E (APOE) polymorphism focusing on connections between the APOE epsilon2-containing genotypes and impairments in instrumental activities of daily living (IADLs) in older (> or = 65) men and women and to examine how diagnosed coronary heart disease (CHD), Alzheimer's disease, colorectal cancer, macular degeneration, and atherosclerosis may mediate these connections. Retrospective cross-sectional study. The unique disability-focused data from a genetic subsample of the 1999 National Long Term Care Survey linked with Medicare service use files. One thousand seven hundred thirty-three genotyped individuals interviewed regarding IADL disabilities. Indicators of IADL impairments, five geriatric disorders, and epsilon2-containing genotypes. The epsilon2/3 genotype is a major contributor to adverse associations between the epsilon2 allele and IADL disability in men (odds ratio (OR)=3.09, 95% confidence interval (CI)=1.53-6.26), although it provides significant protective effects for CHD (OR=0.55, 95% CI=0.33-0.92), whereas CHD is adversely associated with IADL disability (OR=2.18, 95% CI=1.28-3.72). Adjustment for five diseases does not significantly alter the adverse as...Continue Reading

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Citations

Jun 19, 2013·Rejuvenation Research·Alexander M Kulminski
Oct 1, 2009·The American Journal of Nursing·Elizabeth C Kudzma, Eileen T Carey
Apr 8, 2014·Journal of Cancer Research and Clinical Oncology·R AnandRichard Kirubakaran
Nov 25, 2011·International Journal of Alzheimer's Disease·Seema PatelMarwan Sabbagh
Mar 1, 2012·Biochimica Et Biophysica Acta·Corey J MillerNamakkal Soorappan Rajasekaran
Mar 10, 2016·Cadernos de saúde pública·Rodrigo Zunzarren MegaleSérgio Viana Peixoto
Aug 14, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Nalini Raghavachari
Jun 29, 2010·Journal of the American Geriatrics Society·Rosa Ana RisquesJunko Oshima
May 26, 2009·Brain Research Reviews·Fei SongPerminder Sachdev

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