Abstract
To reexamine a health-protective role of the common apolipoprotein E (APOE) polymorphism focusing on connections between the APOE epsilon2-containing genotypes and impairments in instrumental activities of daily living (IADLs) in older (> or = 65) men and women and to examine how diagnosed coronary heart disease (CHD), Alzheimer's disease, colorectal cancer, macular degeneration, and atherosclerosis may mediate these connections. Retrospective cross-sectional study. The unique disability-focused data from a genetic subsample of the 1999 National Long Term Care Survey linked with Medicare service use files. One thousand seven hundred thirty-three genotyped individuals interviewed regarding IADL disabilities. Indicators of IADL impairments, five geriatric disorders, and epsilon2-containing genotypes. The epsilon2/3 genotype is a major contributor to adverse associations between the epsilon2 allele and IADL disability in men (odds ratio (OR)=3.09, 95% confidence interval (CI)=1.53-6.26), although it provides significant protective effects for CHD (OR=0.55, 95% CI=0.33-0.92), whereas CHD is adversely associated with IADL disability (OR=2.18, 95% CI=1.28-3.72). Adjustment for five diseases does not significantly alter the adverse as...Continue Reading
References
May 1, 1976·Medical Care·S Katz, C A Akpom
Nov 2, 1994·JAMA : the Journal of the American Medical Association·H M KrumholzL F Berkman
Jan 1, 1994·Social Science & Medicine·L M Verbrugge, A M Jette
Dec 18, 1995·American Journal of Medical Genetics·S M AlbertR Mayeux
Aug 7, 1998·Gerontology·G BaderR Fellin
Jun 24, 1999·The New England Journal of Medicine·J B Martin
Oct 28, 1999·The New England Journal of Medicine
Nov 24, 1999·Gerontology·G ZulianiR Fellin
Jul 21, 2000·Arthritis and Rheumatism·M J PlantJ D Jessop
Sep 14, 2000·American Journal of Human Genetics·S M FullertonC F Sing
Sep 20, 2000·Psychiatric Genetics·N DuranyF F Cruz-Sánchez
Nov 28, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·D G BlazerB Burchett
Mar 8, 2002·American Journal of Epidemiology·June E EichnerBerrit C Stroehla
Dec 27, 2002·JAMA : the Journal of the American Medical Association·Vicki A FreedmanRobert F Schoeni
Jan 17, 2003·Clinical Science·Mark A WatsonAlexandre Loktionov
Nov 5, 2003·Journal of Aging and Health·Dan G BlazerJudith C Hays
Nov 24, 2004·Neurology·M R FarlowH C Charles
Nov 24, 2004·Journal of Atherosclerosis and Thrombosis·Yasumichi Arai, Nobuyoshi Hirose
Nov 12, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·David MelzerDorly J Deeg
Jan 24, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·José V SorlíOlga Portolés
Feb 16, 2006·Archives of Neurology·Xuemei HuangCharles Poole
Feb 21, 2006·Clinical Endocrinology·Riikka RontuTerho Lehtimäki
Mar 3, 2006·Genes and Immunity·D I ChasmanP M Ridker
May 25, 2006·JAMA : the Journal of the American Medical Association·Sharon ParmetRichard M Glass
Sep 15, 2006·Journal of the American Geriatrics Society·Francesc FormigaRamón Pujol
Oct 6, 2006·The New England Journal of Medicine·Paulus T V M de Jong
Nov 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kenneth G MantonVicki L Lamb
Jan 11, 2007·Archives of Ophthalmology·Gabriella TikellisTien Y Wong
May 23, 2007·Autoimmunity·Birgit VogtAhmed Sheriff
Sep 5, 2007·Journal of the American Geriatrics Society·Alexander M KulminskiAnatoli I Yashin
Citations
Jul 20, 2010·Age·Maria G MateraAlberto Pilotto
Nov 16, 2010·Age·Davide SeripaAlberto Pilotto
Oct 26, 2012·Rejuvenation Research·Alexander M KulminskiAnatoli I Yashin
Jun 19, 2013·Rejuvenation Research·Alexander M Kulminski
Oct 1, 2009·The American Journal of Nursing·Elizabeth C Kudzma, Eileen T Carey
Apr 8, 2014·Journal of Cancer Research and Clinical Oncology·R AnandRichard Kirubakaran
Nov 25, 2011·International Journal of Alzheimer's Disease·Seema PatelMarwan Sabbagh
Dec 9, 2014·Rejuvenation Research·Alexander M KulminskiAnatoli I Yashin
Jul 23, 2016·Biogerontology·Alexander M KulminskiAnatoliy I Yashin
Mar 1, 2012·Biochimica Et Biophysica Acta·Corey J MillerNamakkal Soorappan Rajasekaran
Mar 31, 2015·Scientific Reports·Chunhua YangBin Wang
Mar 10, 2016·Cadernos de saúde pública·Rodrigo Zunzarren MegaleSérgio Viana Peixoto
Dec 25, 2012·Orvosi hetilap·Csaba VéghZsolt B Nagy
Aug 14, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Nalini Raghavachari
Jun 29, 2010·Journal of the American Geriatrics Society·Rosa Ana RisquesJunko Oshima
May 26, 2009·Brain Research Reviews·Fei SongPerminder Sachdev