Health-related quality of life after chemotherapy for advanced germ cell tumors: a comparison of standard-dose and high-dose chemotherapy

International Journal of Urology : Official Journal of the Japanese Urological Association
Hideaki MiyakeIsao Hara

Abstract

The objective of this study was to evaluate the health-related quality of life (HRQoL) in patients with germ cell tumors who received standard-dose chemotherapy or high-dose chemotherapy combined with peripheral blood stem cell transplantation (PBSCT), and to compare the HRQoL of these patients with patients who had undergone surveillance therapy only. Among the 102 patients included in this study, 38 underwent standard-dose cisplatin-based combination chemotherapy alone, 24 received high-dose chemotherapy with PBSCT following standard-dose chemotherapy, and 40 underwent surveillance monitoring. HRQoL was evaluated using the SF-36 survey, which contains 36 questions that assess eight quality-of-life aspects, including physical functioning, role-physical functioning, bodily pain, general health, vitality, social functioning, role-emotional functioning and mental health. The follow-up period of the surveillance group was significantly longer than that of the remaining two groups receiving chemotherapy; however, scale scores were not affected by the duration of follow up in either group. No significant difference was observed in any scale scores between the patients undergoing chemotherapy and those in the surveillance group. In c...Continue Reading

References

Mar 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N S StuartM H Cullen
Dec 1, 1989·The Journal of Urology·M TamburiniV Ventafridda
Aug 25, 1999·World Journal of Urology·A Heidenreich, R Hofmann
Nov 5, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C BokemeyerC Nichols
Jun 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R J MotzerG J Bosl

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Citations

Nov 29, 2015·Journal of Cancer Education : the Official Journal of the American Association for Cancer Education·Marta Dąbrowska-BenderAnna Staniszewska
Jun 18, 2021·Patient Related Outcome Measures·Rebecca Mercieca-BebberMartin R Stockler

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