Health related quality of life after combined hormone replacement therapy: randomised controlled trial.

BMJ : British Medical Journal
Amanda J WeltonWISDOM team

Abstract

To assess the effect of combined hormone replacement therapy (HRT) on health related quality of life. Randomised placebo controlled double blind trial. General practices in United Kingdom (384), Australia (94), and New Zealand (24). Postmenopausal women aged 50-69 at randomisation; 3721 women with a uterus were randomised to combined oestrogen and progestogen (n=1862) or placebo (n=1859). Data on health related quality of life at one year were available from 1043 and 1087 women, respectively. Conjugated equine oestrogen 0.625 mg plus medroxyprogesterone acetate 2.5/5.0 mg or matched placebo orally daily for one year. Health related quality of life and psychological wellbeing as measured by the women's health questionnaire. Changes in emotional and physical menopausal symptoms as measured by a symptoms questionnaire and depression by the Centre for Epidemiological Studies depression scale (CES-D). Overall health related quality of life and overall quality of life as measured by the European quality of life instrument (EuroQol) and visual analogue scale, respectively. After one year small but significant improvements were observed in three of nine components of the women's health questionnaire for those taking combined HRT compar...Continue Reading

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Methods Mentioned

BETA
hormone replacement therapy
hysterectomy

Software Mentioned

Stata
WISDOM

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