Health-related quality of life after open and robot-assisted radical prostatectomy in low- and intermediate-risk prostate cancer patients: a propensity score-matched analysis.

World Journal of Urology
Alexander KretschmerChristian G Stief

Abstract

Introduction of robot-assisted radical prostatectomy (RARP) has revolutionized the therapeutic landscape of organ-confined prostate cancer (PCa). However, comparative analyses focused on health-related quality of life (HRQOL) after RARP and open retropubic prostatectomy (ORP) are sparse. In the current retrospective analysis, inclusion criteria encompassed PSA ≤ 10 ng/ml, ≤ pT2c, ISUP ≤ 3, age ≤ 65 years, and preoperative continence. A propensity score-matched patient cohort [n = 418 (ORP: 209, RARP: 209)] was created and HRQOL was prospectively assessed based on validated questionnaires (EORTC QLQ-C30) preoperatively, 3 months, 12 months, and 24 months postoperatively. Primary endpoint was good general HRQOL based on previously published cut-off values. Erectile function was measured via IIEF-5, urinary continence via ICIQ-SF questionnaire. Multivariable analysis included binary logistic regression models (p < 0.05). Open retropubic prostatectomy and RARP cohorts were well balanced. General HRQOL was significantly higher for ORP compared to RARP after 3 months (70.1 vs. 61.6, p = 0.001), but not at the remaining follow-up time points. There were no significant differences for the remaining QLQ-C30 functioning and symptom score...Continue Reading

References

Apr 3, 2003·Urology·Roland F Van VelthovenRalph V Clayman
Jul 1, 2004·Neurourology and Urodynamics·Kerry AveryPaul Abrams
Mar 28, 2013·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Claire F SnyderAlbert W Wu
Oct 14, 2014·European Urology·Anna WallerstedtUNKNOWN LAPPRO steering committee
Mar 21, 2015·World Journal of Urology·Alexander KretschmerDerya Tilki
Sep 16, 2016·Lancet· The Lancet
May 14, 2017·European Urology·Annika HerlemannMatthew R Cooperberg
Oct 17, 2018·Current Opinion in Urology·Alberto MartiniAlberto Briganti

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