Health-Related Quality of Life After Pancreatectomy: Results From a Randomized Controlled Trial

Annals of Surgical Oncology
Anne A EatonPeter J Allen

Abstract

A recent prospective randomized trial demonstrated that prophylactic pasireotide reduces the incidence of pancreatic complications (PC) after resection. This secondary analysis aimed to describe quality of life (QoL) before and after resection, to characterize the impact of PC on QoL, and to assess whether pasireotide improves QoL. A randomized, double-blind, placebo-controlled trial of preoperative pasireotide in patients undergoing pancreatectomy was conducted. Participants completed the European Organization for Research and Treatment of Cancer (EORTC) C30 and PAN26 modules preoperatively and on postoperative days 14 and 60. Scores were compared using t tests. The percentage of patients with clinically important worsening (a decline ≥0.5 times the baseline standard deviation) was reported. All questionnaires were completed by 87 % (260/300) of the patients. No major differences were observed between the pasireotide and placebo groups. Therefore, the data were pooled for further analyses. A significant worsening of function at 14 days was detected on all the PAN26 and C30 function scales except hepatic and emotional functioning (EF), and on all the C30 symptom scales. More than 75 % of the patients experienced clinically impo...Continue Reading

References

May 1, 1996·The British Journal of Surgery·C SpertiS Pedrazzoli
Oct 26, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D FitzsimmonsT Tihanyi
Dec 4, 2003·Occupational Therapy International·Nichola Jane Spalding
Jan 27, 2005·The British Journal of Surgery·E J M Nieveen van DijkumD J Gouma
Jun 17, 2006·The British Journal of Surgery·B SchniewindT Kuechler
Mar 5, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Stefano CrippaCarlos Fernández-del Castillo
May 23, 2014·The New England Journal of Medicine·Peter J AllenWilliam R Jarnagin
Jun 8, 2015·Current Opinion in Oncology·Gianmauro NumicoNicola Silvestris
Jun 27, 2015·Current Hematologic Malignancy Reports·Julie McNulty, Nandita Khera

❮ Previous
Next ❯

Citations

Sep 9, 2016·World Journal of Gastroenterology : WJG·Nicolò PecorelliMassimo Falconi
Jun 23, 2019·Annals of Surgical Oncology·Robert J TorphyAna Gleisner
Nov 12, 2020·Journal of Hepato-biliary-pancreatic Sciences·Yong Chan ShinJin-Young Jang
Sep 11, 2019·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Michele MolinariAllan Tsung
Aug 23, 2019·Deutsches Ärzteblatt International·Karen SteindorfJoachim Wiskemann
Mar 25, 2021·Annals of Surgical Oncology·Zhi Ven Fong, Cristina R Ferrone

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved