Health-related quality of life and health utilities in insulin-treated type 2 diabetes: the impact of related comorbidities/complications.

The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care
John Yfantopoulos, Athanasios Chantzaras

Abstract

To evaluate the impact of multiple comorbidities/complications on health-related quality of life (HRQoL) and health utilities in insulin-treated type 2 diabetes (T2DM). In a non-interventional, epidemiological study, data were collected from medical records and via interviews for 938 subjects from various geographical areas of Greece. HRQoL and health utilities were explored with the EQ-5D-5L. Univariate associations were evaluated with the Mann-Whitney and Kruskal-Wallis tests for continuous and Chi-squared tests for nominal variables, and binary logistic regressions were employed to obtain marginal effects. Employing a split sample approach, various specifications of ordinary least squares regression models were evaluated in terms of goodness of fit, model specification, shrinkage and predictive and discriminative performance, to select the best model for mapping health utilities using the whole dataset. Overall, the most important factors of impaired HRQoL and health utilities were higher age, female gender, obesity, poor glycemic control and increased duration of insulin treatment. History and increasing concurrence of all complications assessed were associated with exacerbated HRQoL problems, decreased health utilities and...Continue Reading

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Citations

Jul 22, 2021·Journal of Comparative Effectiveness Research·Xuanqian XieAndrei Volodin
Nov 5, 2021·Journal of Medical Economics·Kristina S BoyeLaura Fernández Landó

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