Health-related quality of life and long-term sequelae in survivors of epidermal necrolysis: an observational study of 57 patients.

The British Journal of Dermatology
S Ingen-Housz-OroNicolas de Prost

Abstract

Few studies have investigated the global burden of sequelae and health-related quality of life (HRQoL) for survivors of epidermal necrolysis (EN). To investigate the long-term HRQoL for survivors of EN using validated instruments. We conducted a single-centre study that enrolled patients who were admitted for EN between 2010 and 2017. HRQoL was assessed via phone interview using the Short Form (SF)-36 questionnaire, Hospital Anxiety and Depression (HAD) scale, Impact of Event Scale-Revised, and general quality-of-life outcomes, including EN-specific sequelae. The primary outcome measure was the physical component summary (PCS) score of the SF-36. In total, 57 survivors of EN [19 (33%) with intensive care unit (ICU) admission] were interviewed via telephone at a median of 3·6 years (1·9-6·1) after hospital discharge. The median PCS score was 0·44 SDs below that of the age- and sex-matched reference population and was significantly lower for survivors of EN who were admitted to the ICU vs. those who were not [43·7 (28·7-49·3) vs. 51·2 (39·4-56·5), P = 0·042]. The proportion of patients with EN who had HAD-anxiety score ≥ 8 or HAD-depression score ≥ 5 was 54% and 21%, respectively. Physical and mental outcomes did not differ betwe...Continue Reading

References

Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Nov 17, 1998·Journal of Clinical Epidemiology·A LeplègeT V Perneger
Aug 22, 2000·The Journal of Investigative Dermatology·S Bastuji-GarinP Wolkenstein
Sep 21, 1963·JAMA : the Journal of the American Medical Association·S KATZM W JAFFE
Jan 7, 2004·Behaviour Research and Therapy·Mark CreamerSalvina Failla
Jan 11, 2005·The Journal of Burn Care & Rehabilitation·Julia HaberRobert Cartotto
Jan 9, 2008·Journal of the American Geriatrics Society·Len C GraySergio Ariño-Blasco
Jan 14, 2009·BMJ : British Medical Journal·Despina G Contopoulos-IoannidisJohn P A Ioannidis
Apr 2, 2009·Journal of Evaluation in Clinical Practice·Nicola TorranceMichael I Bennett
Jul 23, 2009·Current Opinion in Critical Care·Jose G M HofhuisPeter E Spronk
Sep 8, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Andrea Vodermaier, Roanne D Millman
Feb 8, 2013·The Journal of Investigative Dermatology·Peggy SekulaUNKNOWN RegiSCAR study group
May 10, 2017·Lancet·Tu Anh DuongOlivier Chosidow
Apr 11, 2018·Orphanet Journal of Rare Diseases·Saskia Ingen-Housz-OroUNKNOWN French National Reference Center for Toxic Bullous Dermatoses
May 15, 2018·The Journal of Investigative Dermatology·Robert G MichelettiMisha Rosenbach
Oct 20, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Damien ContouUNKNOWN Hopeful Study Group

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Citations

Dec 20, 2019·The British Journal of Dermatology·H Y Lee, D Creamer
Jan 27, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·C B Bunker, A B Chapman
Apr 10, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·P MonnetS Ingen-Housz-Oro
Jun 23, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·L Giraud-KerlerouxC Bodemer

Dec 4, 2020·Annales de dermatologie et de vénéréologie·Pr M D'Incan

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