Health-related quality of life and psychological functioning in patients with primary malignant brain tumors: a systematic review of clinical, demographic and mental health factors

Neuro-oncology Practice
Paul D BakerSimon D Kyle

Abstract

The impact of primary malignant brain tumors on patient quality of life and psychological functioning is poorly understood, limiting the development of an evidence base for supportive interventions. We conducted a thorough systematic review and quality appraisal of the relevant literature to identify correlates of health-related quality of life (HRQoL) and psychological functioning (depression, anxiety and distress) in adults with primary malignant brain tumors. Twenty-three articles met predefined inclusion criteria from a pool of peer-reviewed literature published between January 1984 and July 2015 (N = 2407). Methodological quality of included studies was assessed using an adapted version of the Newcastle-Ottawa Scale. The overall methodological quality of the literature was moderate. Factors relating consistently with HRQoL and/or psychological functioning were cognitive impairment, corticosteroid use, current or previous mental health difficulties, fatigue, functional impairment, performance status and motor impairment. Practitioners should remain alert to the presence of these factors as they may indicate patients at greater risk of poor HRQoL and psychological functioning. Attention should be directed towards improving p...Continue Reading

References

Jan 1, 1996·Journal of Neurosurgery·M A WeitznerK Byrne
Aug 17, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·A R Giovagnoli
Oct 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M KleinN K Aaronson
Jan 31, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S KuenstnerO Sezer
Feb 1, 2003·Lancet·Anthony BehinJean-Yves Delattre
Feb 28, 2003·International Journal of Radiation Oncology, Biology, Physics·C A HahnE C Halperin
Feb 26, 2004·Lancet Neurology·Martin J B Taphoorn, Martin Klein
Mar 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·A R GiovagnoliA Boiardi
Mar 31, 2007·Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing·Sherry W FoxElana Farace
Apr 17, 2007·Lancet Neurology·Melanie S M van BreemenCharles J Vecht
May 15, 2007·Sociology of Health & Illness·David ArmstrongSimon Wessely
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Sep 12, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alex J Mitchell
Aug 2, 2008·The New England Journal of Medicine·Patrick Y Wen, Santosh Kesari
Oct 30, 2008·Journal of Cancer Survivorship : Research and Practice·Stephen T KeirHenry S Friedman
Mar 18, 2009·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Erin S CostanzoBurton H Singer
May 8, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Elizabeth A KvaleL B Nabors
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Nov 10, 2009·Lancet·Carole SoussainJean-Yves Delattre
Dec 8, 2009·Sleep Medicine Reviews·Simon D KyleColin A Espie
May 29, 2010·The Oncologist·Martin J B TaphoornAndrew Bottomley
Sep 14, 2010·The American Journal of Hospice & Palliative Care·Kyriaki MystakidouAthanasios Gouliamos
Nov 26, 2010·Journal of the National Cancer Institute·Alasdair G RooneyRobin Grant
Oct 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alasdair G RooneyRobin Grant
Dec 14, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Cagdas YavasFadil Akyol
Feb 7, 2012·Neuro-oncology·Elizabeth FordLesley Fallowfield
Jan 3, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Kimberly R PorterFaith G Davis
Feb 2, 2015·Patient Education and Counseling·Georgia K B HalkettAnna K Nowak

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Citations

Oct 22, 2016·Journal of Aging and Physical Activity·David GeardRylee A Dionigi
Nov 14, 2020·European Journal of Cancer Care·Sung Reul KimWoo-Youl Jang

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