Health-related quality of life anticipated with different management strategies for febrile neutropenia in adult cancer patients.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
O TeuffelS M H Alibhai

Abstract

To describe anticipated health-related quality of life (HRQL) for different hypothetical strategies of febrile neutropenia (FN) management in adult cancer patients. Seventy-eight adult cancer patients were enrolled. Our study considered four different hypothetical treatment strategies for FN: (1) entire inpatient management with intravenous (IV) antibiotics; (2) oral treatment at home after an initial observation in hospital with IV antibiotics; (3) entire outpatient management with IV antibiotics; and (4) entire outpatient management with oral antibiotics. Initially, patients were asked to rank the different treatment strategies for FN based on their personal preference. Subsequently, HRQL was rated using visual analog scale (VAS), time trade-off (TTO), and willingness-to-pay (WTP). Seventy-five percent of all respondents preferred an outpatient strategy for FN (36% oral, 21% intravenous, 18% early discharge). Further, outpatient strategies were associated with higher mean VAS scores (possible range 0-10) (oral: 6.1 (standard deviation (SD) 3.1); intravenous: 6.2 (SD 2.2); early discharge: 5.7 (SD 2.1)) as compared to inpatient care (5.3 (SD 2.9)). On the aggregate level, patients were willing to give up between 9 and 10 weeks...Continue Reading

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Citations

Feb 28, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jean Klastersky, Marianne Paesmans
May 17, 2014·Expert Review of Pharmacoeconomics & Outcomes Research·Kristina S BoyeJessica B Jordan
Jan 14, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jessica E MorganRobert S Phillips
Dec 8, 2014·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Louis S MatzaDavid H Feeny
Jan 30, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Monica A Slavin, Karin A Thursky
Feb 13, 2016·Journal of Oncology Practice·Caitriona B O'NeillElena B Elkin
Oct 13, 2017·Internal Medicine Journal·Nivanka De SilvaChristopher Steer
Dec 30, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jessica E MorganKarl Atkin

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