Health-related quality of life assessment at presentation may predict complications and early relapse in patients with localized cancer of the esophagus

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
L A HealyJ V Reynolds

Abstract

Health-related quality of life (HR-QOL) assessment in esophageal cancer is increasingly performed. However, the association of baseline HR-QOL in predicting outcome is unclear. This study aimed to assess the impact of HR-QOL scores at diagnosis with major morbidity, mortality, failure to progress to surgery, recurrence within 1 year, and survival in patients with localized esophageal cancer. The European Organization for Research and Treatment of Cancer's quality of life questionnaire was completed at diagnosis. Univariate and multivariate logistic regression were used to investigate the relationship between baseline HR-QOL and outcomes adjusting for confounding variables. A total of 185 patients with localized esophageal cancer were included, 89 undergoing multimodal therapy and 96 surgery alone. Global QOL scores were significantly associated with in-hospital mortality (P = 0.020) but not with major morbidity (P = 0.709) or 1-year survival (P = 0.247). Symptoms of fatigue and dyspnea at baseline were significantly (P < 0.05) associated with major morbidity, in-hospital mortality, and survival in univariate analysis. After adjusting for known confounding variables in multivariate analysis, only worse dyspnea score remained pre...Continue Reading

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Citations

Jul 31, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·M C StauderUNKNOWN EABE Registry Consortium
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