Health-related quality of life before, during and after combination therapy with interferon and ribavirin in unselected Swedish patients with chronic hepatitis C

Scandinavian Journal of Gastroenterology
Anna HollanderOla Weiland

Abstract

To study the relationship between health-related quality of life (HRQOL) and mode of acquisition, treatment discontinuations, drop in haemoglobin levels and treatment outcome in patients with chronic hepatitis C (CHC). Consecutive unselected Swedish patients with CHC completed the SF-36 questionnaire before, during and after treatment with interferon and ribavirin. Results. At baseline, HRQOL was reduced in all SF-36 subscales in our patients (n=147) as compared with the general Swedish population. Former intravenous drug users (IVDUs) scored significantly lower in social function (p=0.03) and mental health (p=0.03) than patients who had acquired their infection from blood transfusions (PTH). A decline of >40 points in HRQOL from baseline to week 12 was noticed in the role limitations-physical (RP) score for the IVDU and PTH groups (p<0.0001 and 0.001, respectively). Patients with a >or=20% fall in haemoglobin levels at treatment week 12 had a significantly poorer RP (p=0.006) and role limitations-emotional score (p<0.02) than patients with a <10% fall. Early treatment dropouts had significantly lower HRQOL scores at baseline than adherent patients. At follow-up, sustained viral responders had significantly higher scores than n...Continue Reading

References

Dec 1, 1995·The American Journal of Surgical Pathology·K P Batts, J Ludwig
Sep 1, 1996·Journal of Clinical Microbiology·L StuyverG Maertens
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G R FosterH C Thomas
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H L Bonkovsky, J M Woolley
Jul 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J E WareG L Davis
Oct 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J RodgerN Crofts
Aug 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M PawlotskyD Dhumeaux
Feb 24, 2001·Journal of Hepatology·J G McHutchisonUNKNOWN Hepatitis Interventional Therapy Group
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David BernsteinJesse Green
Sep 27, 2002·The New England Journal of Medicine·Michael W FriedJian Yu
Oct 3, 2002·Gastroenterology·John G McHutchisonUNKNOWN International Hepatitis Interventional Therapy Group
Aug 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gary L DavisJanice Albrecht
Sep 30, 2003·Scandinavian Journal of Infectious Diseases·Rune WejstålUNKNOWN Swedish National Expert Panel for the treatment of chronic hepatitis C
Jan 31, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Olav DalgardTore Steen
Mar 5, 2004·Annals of Internal Medicine·Stephanos J HadziyannisUNKNOWN PEGASYS International Study Group

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Citations

Jun 6, 2012·Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association·Nahid Dehghan NayeriSomayeh Molaee
Aug 14, 2009·Journal of Viral Hepatitis·G R Foster
Jun 8, 2015·The International Journal on Drug Policy·David WhiteleyAnne Whittaker
Jul 21, 2012·Expert Review of Pharmacoeconomics & Outcomes Research·Xin GaoVinod K Rustgi
Aug 28, 2016·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Zobair M YounossiLinda Henry
Mar 20, 2008·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Bruce R SchackmanIra M Jacobson
Mar 13, 2018·Perspectives in Psychiatric Care·Gergely HorváthGábor Gazdag
Nov 8, 2017·Journal of Viral Hepatitis·D SalmonUNKNOWN ESCMID Study Group for Viral Hepatitis
Apr 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert J FontanaUNKNOWN HALT-C Trial Group
Dec 12, 2017·Biomedical Research·Hiroto Tanaka, Hideyuki Sasaki
Jun 15, 2007·Scandinavian Journal of Gastroenterology·Mathias LidgrenBengt Jönsson
Sep 6, 2013·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Roger T AndersonDennis A Revicki

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