Health-related quality of life in a rare disease: hereditary hemorrhagic telangiectasia (HHT) or Rendu-Osler-Weber disease

Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation
Giovanna PasculliCarlo Sabbà

Abstract

The levels of the health-related quality of life (HR-QoL) were analyzed in hereditary hemorrhagic telangiectasia (HHT) patients. The Short Form-36 Health Survey (SF-36) was administered to 50 HHT patients and scores were compared to a cohort of 2301 normal subjects. Clinical variables were patient age, illness duration, number of epistaxis episodes in the previous year and hemoglobin levels. Physical functioning, physical role limitations, bodily pain, social functioning, emotional role limitations and the physical component scores were lower among females. In multivariable analyses increasing age was related to lower physical functioning (p < 0.04), physical role limitations (p < 0.008), bodily pain (p < 0.05) and emotional role limitations (p < 0.01), while higher hemoglobin levels improved physical functioning (p < 0.03). The number of epistaxis episodes was negatively associated with physical role limitations (p < 0.009), vitality (p < 0.002), social functioning (p < 0.001), physical component summary (p < 0.001) and bodily pain (p < 0.01). Illness duration was negatively related to the mental component summary (p < 0.004). HHT patients had a lower HR-QoL with respect to normal controls in all domains except for bodily pain...Continue Reading

References

Sep 11, 1991·The Laryngoscope·O S AAssarR I White
Feb 1, 1988·Pain·Michael Von KorffAndrea Kruger
Nov 1, 1986·Gastroenterology·P Vase, O Grove
Oct 5, 1995·The New England Journal of Medicine·A E GuttmacherR I White
Nov 1, 1996·Journal of Vascular and Interventional Radiology : JVIR·R I WhiteJ A Wirth
Apr 30, 1998·Psychosomatic Medicine·K Kroenke, R L Spitzer
Nov 17, 1998·Journal of Clinical Epidemiology·G Apolone, P Mosconi
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H L Bonkovsky, J M Woolley
Apr 24, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·N Saviolo-NegrinA Girolami
Jan 15, 2000·Scandinavian Journal of Gastroenterology·C Weik, L Greiner
Apr 6, 2000·American Journal of Medical Genetics·C L ShovlinH Plauchu
Mar 23, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Julie RatcliffeUNKNOWN Cost-Effectiveness of Liver Transplantation Team
Oct 19, 2002·The British Journal of Ophthalmology·S ArséneF Tranquart

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Citations

Oct 12, 2012·Annals of Hematology·Christine Priscilla EdwardsMarie E Faughnan
May 5, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Urban W GeisthoffJochem König
Jan 16, 2007·Medicine·Vincent CottinUNKNOWN Groupe d'Etudes et de Recherche sur les Maladies "Orphelines" Pulmonaires (GERM"O"P)
Jul 21, 2007·Respiration; International Review of Thoracic Diseases·Vincent CottinJean-François Cordier
Jun 8, 2012·Disability and Rehabilitation·Amy Østertun GeirdalKetil Heimdal
Feb 4, 2016·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Z-C LiuY-X Chen
Oct 22, 2008·Acta otorrinolaringológica española·José L Alonso-TreceñoJorge Freijanes-Otero
Dec 31, 2015·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Mark Bastianelli, Shaun J Kilty
Mar 18, 2009·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Charlène E U OduberChantal M A M van der Horst
Jul 26, 2014·Orphanet Journal of Rare Diseases·Giuseppe A LatinoMarie E Faughnan
Apr 25, 2012·American Journal of Medical Genetics. Part a·Amy Østertun GeirdalKetil Heimdal
Jan 21, 2010·The Laryngoscope·Jeffrey B HoagChristian A Merlo
Aug 26, 2014·International Forum of Allergy & Rhinology·Christian A MerloDouglas D Reh
Apr 29, 2010·American Journal of Medical Genetics. Part a·Julie S Cohen, Barbara B Biesecker
Jul 30, 2014·Annals of Hematology·Nusrat ZaffarNadine Shehata
Jan 25, 2017·Health and Quality of Life Outcomes·Roberto ZarrabeitiaJosé Antonio Parra
Feb 23, 2018·The Laryngoscope·Johan SteinegerSinan Dheyauldeen
Apr 19, 2017·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jia FangKaiming Su
Aug 9, 2011·American Journal of Rhinology & Allergy·Sinan DheyauldeenGregor Bachmann-Harildstad
Feb 3, 2018·International Forum of Allergy & Rhinology·Ashleigh A HaldermanBradley F Marple
Sep 12, 2018·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Yuan-Pin HsuChiehfeng Chen
May 17, 2005·Journal of Thrombosis and Haemostasis : JTH·C Sabbà
Dec 17, 2010·World Journal of Radiology·Poul Erik Andersen, Anette Drøhse Kjeldsen
Jan 8, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·David E TunkelTaskin M Monjur
Jan 8, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Guillaume MartinentSylvie Fourdrinoy
Jul 10, 2019·The Laryngoscope·Johan SteinegerSinan Dheyauldeen
Sep 8, 2020·Annals of Internal Medicine·Marie E FaughnanRoberto Zarrabeitia
Dec 13, 2005·QJM : Monthly Journal of the Association of Physicians·M GallitelliC Sabbà
Jan 17, 2019·Acta Odontologica Scandinavica·Solfrid Sørgjerd SaltnesHilde Nordgarden
Jan 2, 2019·Laryngoscope Investigative Otolaryngology·Marci ClarkJeffrey B Hoag
Aug 28, 2020·Journal of Clinical Medicine·Alexandra KilianUNKNOWN the Brain Vascular Malformation Consortium HHT Investigator Group
May 11, 2018·American Journal of Rhinology & Allergy·Ashleigh A HaldermanDavid M Poetker
Oct 7, 2020·JAMA Otolaryngology-- Head & Neck Surgery·Andrew M PetersonJay F Piccirillo

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