Health-related quality of life in a rare disease: hereditary hemorrhagic telangiectasia (HHT) or Rendu-Osler-Weber disease

Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation
Giovanna PasculliCarlo Sabbà


The levels of the health-related quality of life (HR-QoL) were analyzed in hereditary hemorrhagic telangiectasia (HHT) patients. The Short Form-36 Health Survey (SF-36) was administered to 50 HHT patients and scores were compared to a cohort of 2301 normal subjects. Clinical variables were patient age, illness duration, number of epistaxis episodes in the previous year and hemoglobin levels. Physical functioning, physical role limitations, bodily pain, social functioning, emotional role limitations and the physical component scores were lower among females. In multivariable analyses increasing age was related to lower physical functioning (p < 0.04), physical role limitations (p < 0.008), bodily pain (p < 0.05) and emotional role limitations (p < 0.01), while higher hemoglobin levels improved physical functioning (p < 0.03). The number of epistaxis episodes was negatively associated with physical role limitations (p < 0.009), vitality (p < 0.002), social functioning (p < 0.001), physical component summary (p < 0.001) and bodily pain (p < 0.01). Illness duration was negatively related to the mental component summary (p < 0.004). HHT patients had a lower HR-QoL with respect to normal controls in all domains except for bodily pain...Continue Reading


Sep 11, 1991·The Laryngoscope·O S AAssarR I White
Feb 1, 1988·Pain·Michael Von KorffAndrea Kruger
Nov 1, 1986·Gastroenterology·P Vase, O Grove
Oct 5, 1995·The New England Journal of Medicine·A E GuttmacherR I White
Nov 1, 1996·Journal of Vascular and Interventional Radiology : JVIR·R I WhiteJ A Wirth
Apr 30, 1998·Psychosomatic Medicine·K Kroenke, R L Spitzer
Nov 17, 1998·Journal of Clinical Epidemiology·G Apolone, P Mosconi
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H L Bonkovsky, J M Woolley
Apr 24, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·N Saviolo-NegrinA Girolami
Jan 15, 2000·Scandinavian Journal of Gastroenterology·C Weik, L Greiner
Apr 6, 2000·American Journal of Medical Genetics·C L ShovlinH Plauchu
Mar 23, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Julie RatcliffeUNKNOWN Cost-Effectiveness of Liver Transplantation Team
Oct 19, 2002·The British Journal of Ophthalmology·S ArséneF Tranquart

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