Health-related quality of life in children and young adults with post-thrombotic syndrome: results from a cross-sectional study

Pediatric Blood & Cancer
Riten KumarJohn A Heit

Abstract

While post-thrombotic syndrome (PTS) is increasingly recognized in children with a history of deep vein thrombosis (DVT), its impact on the health-related quality of life (HRQoL) is unknown. Our objective was to evaluate the association between the PTS and HRQoL by surveying a cohort of patients treated at our institution for DVT. All unique pediatric patients (0-18 years) treated for a DVT at the Mayo Clinic during the 15-year period, 1995-2009 were identified. A previously validated PTS survey instrument and age appropriate Pediatric Quality of Life inventory, version 4 (PedsQL 4.0) were mailed to eligible patients. Linear regression models were fit to compare the HRQoL scores between PTS groups (none, mild, moderate/severe), after adjusting for the presence of potential covariates. Of the 90 respondents, 65 (72%) reported signs and/or symptoms of PTS. Mean age (± SD) at DVT diagnosis and survey completion were 12.8 (± 6.1) and 19.3 (± 7.7) years, respectively. Self-report PedsQL 4.0 module was completed by 79 patients, and 34 guardians completed the parent-proxy module. Patients with moderate to severe PTS reported significantly worse total HRQoL score (mean ± SD, 71.3 ± 13.4) as compared to patients with mild PTS (84.8 ± 14...Continue Reading

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Citations

Aug 12, 2014·The Journal of Pediatrics·Arash Mahajerin, Courtney D Thornburg
Oct 7, 2016·Journal of Thrombosis and Haemostasis : JTH·M L AvilaB M Feldman
Jan 26, 2017·Phlebology·Klara VosickaAlun H Davies
Jun 5, 2018·Phlebology·Mohamed Ah TahaAlun H Davies
Jul 3, 2020·Journal of Thrombosis and Haemostasis : JTH·Elissa R EngelMarisol Betensky
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Dec 23, 2017·Frontiers in Pediatrics·Cristina Tarango, Marilyn J Manco-Johnson
Aug 28, 2020·TH Open : Companion Journal to Thrombosis and Haemostasis·Deepti M WaradVilmarie Rodriguez
Dec 12, 2018·The Journal of Pediatrics·Cedric ManlhiotLeonardo R Brandão

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