Health-Related Quality of Life in Children and Adults with Primary Immunodeficiencies: A Systematic Review and Meta-Analysis

The Journal of Allergy and Clinical Immunology. in Practice
Dmitrii PeshkoDaniel Munblit

Abstract

Primary immunodeficiency diseases (PIDs) are a group of diseases that have been found to have an adverse impact on quality of life and health-related quality of life (HRQOL). To systematically assess available evidence on the HRQOL of patients with PID. We performed a literature search of all studies reporting HRQOL assessments in patients with PID published in English from inception to April 11, 2017, using MEDLINE and EMBASE. Of 1699 articles, 37 met the inclusion criteria. HRQOL was assessed by using various generic instruments. Child Health Questionnaire - Parent Form 50 and short-form 36 were the most frequently used (for children and adults, respectively). No PID-specific HRQOL instruments were used for children. HRQOL is significantly lower in adults with PID (mean score difference, -24.46; 95% CI, -34.57 to -14.34) and children (-10.06; 95% CI, -12.95 to -7.17) compared with the reference population and lower than in patients with other chronic conditions. There is a general agreement between child- and parent-reported data, although parents report child school-related HRQOL as more impaired than do children (6.19; 95% CI, 0.38 to 11.99). Most studies were of low to moderate quality and had methodological limitations. A...Continue Reading

Citations

Apr 16, 2020·Journal of Clinical Immunology·Saida Ridao-ManonellasPere Soler-Palacín
Mar 21, 2020·Frontiers in Immunology·Ilya KorsunskiyDaniel Munblit
Oct 23, 2020·Arthritis Care & Research·Erin B Treemarcki, Aimee O Hersh
Sep 22, 2021·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Laia AlsinaLuis Ignacio González-Granado

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