Abstract
To compare health-related quality of life (HRQoL) in colorectal cancer (CRC) survivors with sporadic CRC to those with hereditary cancer, specifically Lynch syndrome (LS). Participants completed a mailed self-administered questionnaire that assessed, among other things, demographics, clinical characteristics, and health-related quality of life. Using a case-case design, CRC survivors with LS or sporadic cancer were matched on age, sex, race/ethnicity, cancer stage, geography, and time since diagnosis. Participants were recruited from patient registries at The University of Texas MD Anderson Cancer Center (MD Anderson) (n = 33 LS; n = 75 sporadic) and through social media (n = 42 LS). The final sample included 71 LS and 74 sporadic CRC survivors. For LS patients, the mean FACT-C HRQoL score was 84.8 (11.9) [Median = 86.0; Interquartile Range-17] compared to sporadic patients mean score of 85.8 (16.7) [Median = 92.0; Interquartile Range-21], which indicates high quality of life for both groups. LS patients and sporadic CRC patients had similar HRQoL mean scores across 7 different HRQoL metrics, with no significant differences between groups. Exploratory regression analyses indicate some differences in known predictors of HRQoL by...Continue Reading
References
Mar 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D F CellaJ Brannon
Feb 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Sep 3, 1999·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·W L WardD Cella
Mar 7, 2003·The New England Journal of Medicine·Henry T Lynch, Albert de la Chapelle
Dec 18, 2003·Health and Quality of Life Outcomes·Kimberly WebsterKathleen Yost
Jun 7, 2005·Journal of Medical Genetics·F QuehenbergerH C van Houwelingen
Aug 9, 2005·Gastroenterology·Heather HampelAlbert de la Chapelle
Sep 28, 2006·JAMA : the Journal of the American Medical Association·Sining ChenUNKNOWN Colon Cancer Family Registry
Sep 28, 2006·JAMA : the Journal of the American Medical Association·Noralane M LindorNancy Press
Dec 14, 2007·Biological Research for Nursing·Emma L Kurnat-Thoma
Jul 8, 2008·Gastroenterology·Leigha SenterAlbert de la Chapelle
Aug 6, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Henry T LynchThomas A Attard
Dec 24, 2009·Journal of the National Cancer Institute·Laura BagliettoMark A Jenkins
Apr 28, 2010·Gastroenterology·Kory W JaspersonRandall W Burt
Jan 8, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Elena PizzoSergio Gullini
Sep 9, 2011·Hereditary Cancer in Clinical Practice·Kathy E WatkinsPatrick S Parfrey
Jul 13, 2013·Health and Quality of Life Outcomes·Salvador Pita-FernándezAlejandro Pazos-Sierra
Dec 7, 2013·BMC Surgery·Stefano MarventanoAntonio Biondi
Jun 25, 2014·JSLS : Journal of the Society of Laparoendoscopic Surgeons·George E Theodoropoulos, Theodoros Karantanos
Jul 30, 2014·The American Journal of Gastroenterology·Francis M GiardielloDouglas K Rex
Oct 10, 2014·Clinical Genetics·M J EsplenS Gallinger
Jan 7, 2015·Journal of Personalized Medicine·Yen Y Tan, Lisa J Fitzgerald
Mar 13, 2016·Clinical Colorectal Cancer·Lisette M WiltinkCorrie A M Marijnen