Health-related quality of life in HIV-infected naive patients treated with nelfinavir or nevirapine associated with ZDV/3TC (the COMBINE-QoL substudy)

HIV Clinical Trials
A CasadoCOMBINE Study Team

Abstract

The aim of the study was to assess differences in health-related quality of life (HRQoL) in HIV-infected naive patients treated with two HAART regimens at 12 months. The MOS-HIV questionnaire was used to measure HRQoL in a subgroup of 127 patients included in the COMBINE study, which was an open-label, randomized, multicenter study comparing zidovudine (ZDV) and lamivudine (3TC) plus nelfinavir (NFV) or nevirapine (NVP) regimens in HIV-infected naive patients. 63 patients were included in the ZDV/3TC/NFV arm and 64 in the ZDV/3TC/NVP arm. No statistically significant differences were observed at baseline in demographic and clinical variables and HRQoL scores between treatment groups, except that the proportion of homosexual men was higher in the ZDV/3TC/NVP arm. There were no statistically significant differences in HRQoL scores between arms at 12 months and over time; only ZDV/3TC/NVP patients showed statistically significant improvement in Physical Health Summary score (p <.01) and a trend toward a better profile in Mental Health Summary score (p =.07). Overall, patients who were treated with ZDV/3TC/NVP showed greater changes in physical dimensions and patients who were treated with ZDV/3TC/NFV showed greater changes in ment...Continue Reading

References

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Citations

Dec 12, 2007·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Diane L FaircloughAlbert W Wu
Jul 27, 2006·Expert Opinion on Drug Metabolism & Toxicology·Montserrat Olmo, Daniel Podzamczer
Jun 25, 2008·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Keswadee LapphraKulkanya Chokephaibulkit
Jul 19, 2008·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Midion Mapfumo Chidzonga, Leonard Mahomva
Oct 27, 2007·AIDS Research and Human Retroviruses·Raffaella BucciardiniUNKNOWN Initio Trial International Coordinating Committee

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