Health-related quality of life in patients with myasthenia gravis and the relationship between patient-oriented assessment and conventional measurements

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
L PaduaP Tonali

Abstract

We assessed the health-related quality of life (HRQoL) of patients with myasthenia gravis (MG) and correlated it with the physician's measurements of MG. Patients with MG were evaluated by means of (1) self-administered questionnaires, (2) clinical examination, (3) Osserman classification, (4) anti-AChR antibody, and (5) neurophysiology. Relationships between patient-oriented assessment and conventional clinical-neurophysiological and serological findings were evaluated. A total of 46 patients, inpatients and outpatients (mean age 50.7 years, range 11-77 years, 17 males, 29 females) with MG diagnosis were studied. The Osserman scale and clinical examination findings were significantly related to the physical aspects of HRQoL. Mental aspects of the quality of life were not progressively involved as muscle deficit progressed, but even in a mild clinical picture, the mental aspects were deteriorated. Patient-oriented measures proved that the patient's quality of life was impaired especially with regard to physical aspects. Our data demonstrated that clinical measurements are related to the HRQoL. The results may be useful in developing a disease-specific patient-oriented tool.

Citations

Feb 3, 2011·Journal of Neurology·Yu-Tai ChenJiann-Horng Yeh
Oct 10, 2009·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Alberto RaggiRenato Mantegazza
Nov 26, 2009·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Alberto RaggiGiulia Fioravanti
May 13, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Kongkiat KulkantrakornSomsak Tiamkao
Aug 10, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ivana Z BastaDragana V Lavrnić
Mar 1, 2012·Chinese Journal of Integrative Medicine·Feng-bin LiuXiao-bin Liu
Feb 24, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A RostedtE V Stålberg
Nov 13, 2010·Health and Quality of Life Outcomes·Sabine TworkJoachim Kugler
Nov 16, 2013·The International Journal of Neuroscience·Alessandra AriattiGiuliana Galassi
May 23, 2015·The International Journal of Neuroscience·Yongxiang YangZhuyi Li
Jun 21, 2013·Disability and Rehabilitation·Alberto RaggiRenato Mantegazza
Nov 20, 2008·Muscle & Nerve·Ted M BurnsUNKNOWN Muscle Study Group
Aug 13, 2008·Muscle & Nerve·Larry L MullinsUNKNOWN Muscle Study Group
Jul 22, 2008·Muscle & Nerve·Ted M BurnsUNKNOWN Muscle Study Group
May 15, 2012·Muscle & Nerve·Michael BenatarUNKNOWN Task Force on MG Study Design of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America
Dec 17, 2009·Acta Neurologica Scandinavica·I BastaD Lavrnić
Jul 19, 2012·Muscle & Nerve·Masayuki MasudaNorihiro Suzuki
Feb 19, 2014·Muscle & Nerve·Kimiaki UtsugisawaNorihiro Suzuki
Jun 29, 2010·Muscle & Nerve·Ted M Burns
Apr 3, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·David CioncoloniFabio Giannini
Mar 1, 2006·Journal of Clinical Neuromuscular Disease·Kevin R Scott, Milind J Kothari
Nov 9, 2010·Clinical Drug Investigation·Corrado Angelini
May 18, 2011·Arthritis Care & Research·Jinoos YazdanyPatricia P Katz
Mar 30, 2018·Acta neurologica Belgica·Milica StankovicIvana Basta
Sep 5, 2020·Health and Quality of Life Outcomes·Dong DongJianfeng Zhu
Aug 18, 2020·Curēus·Christina LawSankar Bandyopadhyay
Oct 20, 2020·Frontiers in Neurology·Piotr SzczudlikAnna Kostera-Pruszczyk
Jun 17, 2021·Acta Neurologica Scandinavica·Juan Pablo ContrerasGabriel Cea
Sep 5, 2021·Journal of Neurology·Ivo BozovicIvana Basta
Nov 21, 2021·Journal of Neurology·Sophie LehnererAndreas Meisel

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