Health-related quality of life in patients with longstanding 'benign multiple sclerosis'

Multiple Sclerosis and Related Disorders
Anna-Marie BuenoHelen Tremlett

Abstract

We explored health-related quality of life (HRQoL) and psychosocial aspects in a cohort of patients with a history of longstanding benign MS (BMS). Patients with BMS (EDSS≤3 after 20 years disease duration) were re-assessed 25-30 years post-MS symptom onset for: EDSS, HRQoL (MSQoL-54), depression (Beck Depression Inventory-II), and fatigue (Modified Fatigue Impact Scale). Associations between these measures and patient characteristics (age, disease duration, 'benign status' [remained benign (EDSS≤3) vs no longer benign (EDSS>3)]) were examined. Of the 61 patients included, 36 (49%) remained benign and 25 (41%) progressed (EDSS>3). Overall, physical and mental HRQoL scores were positively associated with each other (r=0.63; p<0.0001) and both negatively correlated with fatigue (r=-0.76 and -0.44, respectively; p<0.0005) and depression (r=-0.55 and -0.77; p<0.0001). Patients who remained benign reported better physical HRQoL vs those no longer benign (mean (SD)=67.3±18.1 vs 50.7±19.9, p=0.001), but not mental health (mean (SD)=67.4±19.3 vs 65.0±20.6, p=0.639). Generally, neither age nor disease duration was strongly associated with HRQoL (r<0.35). Lower self-reported physical or mental HRQoL was associated with worsening fatigue ...Continue Reading

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Citations

Mar 26, 2016·Disability and Rehabilitation·Yesim GaripTansu Arasil
May 31, 2019·Neurology and Therapy·Maria José Sá
Mar 3, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Loes CrielaardAli Manouchehrinia
Dec 2, 2020·BMJ Open·Irene Gil-GonzálezMaría Ángeles Pérez-San-Gregorio

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