Health-related quality of life in patients with giant cell arteritis treated with tocilizumab in a phase 3 randomised controlled trial

Arthritis Research & Therapy
Vibeke StrandJohn H Stone

Abstract

Patients with giant cell arteritis (GCA) treated with tocilizumab (TCZ) every week or every other week and prednisone tapering achieved superior rates of sustained remission to patients treated with placebo and prednisone tapering in a randomised controlled trial. Health-related quality of life (HRQOL) in patients from this trial is now reported. Exploratory analyses of SF-36 PCS and MCS and domain scores, PtGA and FACIT-Fatigue were performed in patients treated with weekly subcutaneous TCZ 162 mg plus 26-week prednisone taper (TCZ-QW + Pred-26) or placebo plus 26-week or 52-week prednisone tapers (PBO + Pred-26 or PBO + Pred-52). These analyses were performed on responder and non-responder patients, including those who achieved the primary outcome and those who experienced flare and received escape prednisone doses. Baseline SF-36 PCS, MCS and domain scores were low, indicating impaired HRQOL related to GCA. At week 52, least squares mean (LSM) changes in PCS scores improved with TCZ-QW + Pred-26 but worsened in both PBO + Pred groups (p <  0.001). LSM changes in MCS scores increased with TCZ-QW + Pred-26 versus PBO + Pred-52 (p < 0.001). Treatment with TCZ-QW + Pred-26 resulted in significantly greater improvement in four of...Continue Reading

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Citations

Dec 14, 2019·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Alfredo Sadun, Lynn Gordon
Mar 7, 2019·Nature Reviews. Rheumatology·Joanna Collison
Jan 12, 2021·Clinical & Experimental Ophthalmology·Sumu SimonPravin Hissaria
Jan 30, 2021·Current Rheumatology Reports·Joanna RobsonCatherine Hill
May 30, 2021·Annals of the Rheumatic Diseases·Sebastian H UnizonyJohn H Stone
Jan 13, 2022·Rheumatology·Michael PutmanRichard Conway

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Methods Mentioned

BETA
biopsy

Clinical Trials Mentioned

NCT01791153

Software Mentioned

GiACTA

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