Health-Related Quality of Life in Pulmonary Hypertension and Its Clinical Correlates: A Cross-Sectional Study

BioMed Research International
Abílio ReisLuís Almeida

Abstract

Health-related quality of life (HRQoL) impairment is common in pulmonary hypertension (PH), but its clinical predictors are not well established. This study aims to characterize the HRQoL of patients with pulmonary arterial hypertension (PAH) and other precapillary forms of PH (pcPH) and to explore its clinical correlates. A cross-sectional, observational study of patients with documented PAH and other forms of pcPH. Patients completed two patient-reported outcome measures (PROM): Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) and Nottingham Health Profile (NHP). Clinical characteristics were retrieved from electronic medical records. Mean CAMPHOR and NHP scores for the study population were indicative of a moderate HRQoL impairment. Patients in World Health Organisation Functional Classes (WHO FC) III/IV showed significantly worse HRQoL. The main clinical correlates of HRQoL were WHO FC, 6-minute walking distance (6MWD), and Borg dyspnoea index. Overall quality of life (QoL), assessed through CAMPHOR's QoL domain, showed patterns comparable to HRQoL measured by both instruments. HRQoL, measured by two different PROMs, is impaired in Portuguese patients with PAH and other forms of pcPH, particularly in patients with ...Continue Reading

References

Sep 5, 1992·Health Policy·S M Hunt, S P McKenna
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·N NagayaK Miyatake
Sep 3, 2002·Journal of the American College of Cardiology·Olivier SitbonGérald Simonneau
Jul 14, 2004·Chest·Vallerie V McLaughlinUNKNOWN American College of Chest Physicians
Aug 12, 2005·Respiratory Research·Darren B TaichmanHarold Palevsky
Jan 18, 2006·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·S P McKennaJ Pepke-Zaba
May 19, 2006·The European Respiratory Journal·E CenedeseM Fischler
Jan 12, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mardi Gomberg-MaitlandStephen P McKenna
Mar 21, 2008·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Donna CoffinStephen P McKenna
Sep 3, 2011·The European Respiratory Journal·R Condliffe
Sep 14, 2012·Health and Quality of Life Outcomes·Katharina CimaSilvia Ulrich
Sep 15, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Keith M SwetzMichael D McGoon
Nov 16, 2012·The Journal of Cardiovascular Nursing·Lea Ann MaturaDiane L Carroll
Nov 16, 2013·The European Respiratory Journal·Janelle YorkeIain Armstrong
Dec 21, 2013·Journal of the American College of Cardiology·Gerald SimonneauRogiero Souza
Nov 5, 2015·Journal of Exercise Rehabilitation·Arunabh TalwarNina Kohn
Dec 2, 2015·European Respiratory Review : an Official Journal of the European Respiratory Society·Marion Delcroix, Luke Howard
Feb 20, 2016·PharmacoEconomics·Milad Karimi, John Brazier
Jun 16, 2016·Respiratory Research·Deborah McCollisterUNKNOWN IRB information for the 5 clinical sites
Jul 28, 2016·Health and Quality of Life Outcomes·Abílio ReisLuís Almeida

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Citations

May 5, 2020·Pulmonary Circulation·Shelley ShapiroAndrew C Nelsen
Jan 25, 2020·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Pavel JansaAles Linhart
Dec 2, 2020·International Journal of Molecular Sciences·Jordy M M Kocken, Paula A da Costa Martins
Feb 4, 2021·BMC Pulmonary Medicine·Miguel Ángel Amor-GarcíaMaría Sanjurjo-Sáez
Jun 10, 2021·Heart & Lung : the Journal of Critical Care·Leticia Fernanda Tavares Sousa de OliveiraVinicius Batista Santos

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Software Mentioned

SPSS
SYMPACT®
PAHTool®
CAMPHOR
PAH

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