Health-related quality of life in survivors of septic shock: 6-month follow-up from the ADRENAL trial.

Intensive Care Medicine
Naomi E HammondADRENAL Trial Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group

Abstract

To investigate the impact of hydrocortisone treatment and illness severity on health-related quality of life (HRQoL) at 6 months in septic shock survivors from the ADRENAL trial. Using the EuroQol questionnaire (EQ-5D-5L) at 6 months after randomization we assessed HRQoL in patient subgroups defined by hydrocortisone or placebo treatment, gender, illness severity (APACHE II < or ≥ 25), and severity of shock (baseline peak catecholamine doses < or ≥ 15 mcg/min). Additionally, in subgroups defined by post-randomisation variables; time to shock reversal (days), treatment with renal replacement therapy (RRT), and presence of bacteremia. At 6 months, there were 2521 survivors. Of these 2151 patients (85.3%-1080 hydrocortisone and 1071 placebo) completed 6-month follow-up. Overall, at 6 months the mean EQ-5D-5L visual analogue scale (VAS) was 70.8, mean utility score 59.4. Between 15% and 30% of patients reported moderate to severe problems in any given HRQoL domain. There were no differences in any EQ-5D-5L domain in patients who received hydrocortisone vs. placebo, nor in the mean VAS (p = 0.6161), or mean utility score (p = 0.7611). In all patients combined, males experienced lower pain levels compared to females [p = 0.0002). Nei...Continue Reading

Associated Clinical Trials

References

Mar 24, 2010·Critical Care Medicine·Bradford D WintersJonathan E Sevransky
May 25, 2010·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Dasha CherepanovStephanie A Robert
Oct 21, 2010·Critical Care Medicine·Sanjay V DesaiDale M Needham
Nov 28, 2012·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·M F JanssenJan Busschbach
Mar 21, 2013·JAMA : the Journal of the American Medical Association·Steven M OpalUNKNOWN ACCESS Study Group
Jun 15, 2013·Health Economics·Rosalie VineyDeborah Street
Mar 19, 2014·The New England Journal of Medicine·Donald M YealyDerek C Angus
Jun 5, 2015·PharmacoEconomics·Nalin PayakachatJ Mick Tilford
Sep 29, 2015·American Journal of Respiratory and Critical Care Medicine·Carolin FleischmannUNKNOWN International Forum of Acute Care Trialists
Jun 22, 2016·The Lancet. Respiratory Medicine·Colman TaylorUNKNOWN Crystalloid versus Hydroxyethyl Starch Trial (CHEST) investigators and the Australian and New Zealand Intensive Care Society
Jul 20, 2016·Critical Care Medicine·Adam LinderJames A Russell
Nov 19, 2017·Critical Care Clinics·Hallie C Prescott, Deena Kelly Costa
Jan 4, 2018·JAMA : the Journal of the American Medical Association·Hallie C Prescott, Derek C Angus
Jan 20, 2018·The New England Journal of Medicine·Balasubramanian VenkateshUNKNOWN ADRENAL Trial Investigators and the Australian–New Zealand Intensive Care Society Clinical Trials Group
Apr 26, 2018·The New England Journal of Medicine·Balasubramanian VenkateshLaurent Billot
Jun 29, 2018·Intensive Care Medicine·Kelly ThompsonSimon Finfer
Aug 5, 2018·Critical Care : the Official Journal of the Critical Care Forum·Tao YangXiuming Xi
Nov 22, 2018·Critical Care : the Official Journal of the Critical Care Forum·Michael J MasseyUNKNOWN ProCESS investigators
Apr 16, 2019·Critical Care Medicine·Alisa M HigginsUNKNOWN Australasian Resuscitation in Sepsis Evaluation (ARISE) Investigators and the ANZICS Clinical Trials Group
Feb 15, 2020·Critical Care Medicine·Jerry J ZimmermanUNKNOWN Life After Pediatric Sepsis Evaluation (LAPSE) Investigators

❮ Previous
Next ❯

Citations

Dec 1, 2020·Critical Care Explorations·Anne V GrossestreuerMichael W Donnino
Jan 8, 2021·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Stéphane Leteurtre, Morgan Recher
Jul 31, 2021·Australian Critical Care : Official Journal of the Confederation of Australian Critical Care Nurses·Kelly J ThompsonColman B Taylor
Sep 21, 2021·Seminars in Respiratory and Critical Care Medicine·Wagner NedelJorge I F Salluh
Nov 10, 2021·Current Opinion in Infectious Diseases·Alexis TabahJean-François Timsit

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved