In hypertension, tolerability of drug treatment is important because individuals may see the use of antihypertensive medications as more troubling than their seemingly symptomless disease. This may result in noncompliance and ineffectual long term treatment. In the past 15 years, new antihypertensive medications have been marketed on the basis of the advantages they offer with regard to adverse effects and the unavoidable impact of such adverse effects on a person's quality of life. When related to health, quality of life refers to the physical, psychological and social dimensions of health that are influenced by a person's experiences, beliefs, expectations and perceptions. To measure this concept, many instruments, either generic or specific, may be used. The purpose of this study is to describe, by way of a critical review of the literature, the instruments that are most often used in the measurement of health-related quality of life (HR-QOL) in people using antihypertensive drug treatments. We carried out a search of the literature published in English in the period January 1966 to July 2000, looking for randomised controlled trials of antihypertensive drugs. Using the Medline database, we included 77 papers in our review. ...Continue Reading
Quality of life in hypertensives treated with atenolol or captopril: a double-blind crossover trial.
Quality of life: a model for evaluating health for all. Conceptual considerations and policy implications
Impact of diagnosis and treatment of hypertension on quality of life: a double-blind, randomized, placebo-controlled, cross-over study of betaxolol
Superiority of nonpharmacologic therapy compared to propranolol and placebo in men with mild hypertension: a randomized, prospective trial.
Effects of diltiazem and metoprolol on blood pressure, adverse symptoms and general well-being. The Swedish Diltiazem-Metoprolol Multi-Centre Study Group
A randomized controlled trial of the effects of three antihypertensive agents on blood pressure control and quality of life in older women
Antihypertensive efficacy and tolerability of enalapril and slow-release verapamil in essential hypertension: a double-blind, cross-over study
Assessment of quality of life by patient and spouse during antihypertensive therapy with atenolol and nifedipine gastrointestinal therapeutic system
Quality of life on antihypertensive therapy: a randomized double-blind controlled trial of captopril and atenolol
Quality of life among hypertensive patients with a diuretic background who are taking atenolol and enalapril
Developing a model for the study of quality of life in elderly patients with chronic disease: use of hypertension as an example
Comparison of a lifestyle modification program with propranolol use in the management of diastolic hypertension
Comparison of verapamil and captopril in elderly hypertensive subjects: results of a randomized, double-blind, crossover study
Parallel perspectives on quality of life during antihypertensive therapy: impact of responder, survey environment, and questionnaire structure
Effects of 100 mg of controlled-release metoprolol and 100 mg of atenolol on blood pressure, central nervous system-related symptoms, and general well being
Doxazosin and captopril in mildly hypercholesterolemic hypertensive patients. The Doxazosin-Captopril in Hypercholesterolemic Hypertensives Study
Quality of life and antihypertensive therapy in men. A comparison of captopril with enalapril. The Quality-of-Life Hypertension Study Group
A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension
A randomized comparison of the effect of four antihypertensive monotherapies on the subjective quality of life in previously untreated asymptomatic patients: field trial in general practice. The OCAPI Study Group. Optimiser le Choix d'un Anti-hypertenseur de Première Intention
Alpha-blockade and thiazide treatment of hypertension. A double-blind randomized trail comparing doxazosin and hydrochlorothiazide
Efficacy, tolerability, and quality of life of losartan, alone or with hydrochlorothiazide, versus nifedipine GITS in patients with essential hypertension
Effect of angiotensin converting enzyme inhibitors on quality of life in hypertensive patients. Pharmacodynamic basis
Effect of blood pressure control and antihypertensive drug regimen on quality of life: the African American Study of Kidney Disease and Hypertension (AASK) Pilot Study
Analysis of adverse effects among patients with essential hypertension receiving an ACE inhibitor or a beta-blocker
Improved quality of life in patients with generalized cardiovascular metabolic disease on a prepared diet
The effects of replacing beta-blockers with an angiotensin converting enzyme inhibitor on the quality of life of hypertensive patients
Relationships of quality-of-life measures to long-term lifestyle and drug treatment in the Treatment of Mild Hypertension Study
Measuring health-related quality of life in rheumatoid arthritis: validity, responsiveness and reliability of EuroQol (EQ-5D)
Additive effects of diltiazem and lisinopril in the treatment of elderly patients with mild-to-moderate hypertension
Quality of life in randomized trials of cytotoxic or hormonal treatment of advanced breast cancer. Is there added value?
Effect of valsartan on quality of life when added to usual therapy for heart failure: results from the Valsartan Heart Failure Trial
Protective effect of anti-hypertensive treatment on cognitive function in essential hypertension: analysis of published clinical data
Health-related quality of life in patients treated for hypertension: a review of the literature from 1990 to 2000
Functional outcomes of multi-condition collaborative care and successful ageing: results of randomised trial.
Are all outcomes in chronic heart failure rated equally? An argument for a patient-centred approach to outcome assessment
Does lowering blood pressure with antihypertensive therapy preserve independence in activities of daily living? A systematic review
Longitudinal predictors of health-related quality of life in middle-aged and older adults with hypertension: results of a population-based study
An evaluation of the effects of an angiotensin receptor blocker on health-related quality of life in patients with high-normal blood pressure (prehypertension) in the Trial of Preventing Hypertension (TROPHY).
Health-related quality of life in hypertension, chronic kidney disease, and coexistent chronic health conditions.
Antihypertensive Agents: Mechanisms of Action
Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.