Health-related quality of life outcomes from botulinum toxin treatment in hemifacial spasm

Therapeutic Advances in Neurological Disorders
Daniel WeissTobias Wächter

Abstract

Although botulinum neurotoxin (BoNT) injections may alleviate involuntary muscle contractions in hemifacial spasm substantially, it is less clear whether the motor effect would translate into improvements of health-related quality of life (HR-QoL). In this open-label clinical observational study, we characterized outcomes on HR-QoL in terms of the EuroQol (EQ-5D-5L) from BoNT in a prospective cohort of patients with hemifacial spasm (n = 73). Additionally, we characterized appendicular motor and nonmotor signs on motor symptom improvement, depressive symptoms, pain and sleep quality. Patients were assessed at the end of a regular 3-month period from last injection (timepoint1) and 4 weeks after the reinjection of BoNT (timepoint2). Patients showed improved HR-QoL on the EQ-VAS (visual analogue scale) at timepoint2 compared with timepoint1. Moreover, we identified, that impairments in HR-QoL at timepoint1 correlated with life satisfaction and depressive symptoms, respectively. However, these associated variables did not predict the therapeutic effect. Instead, EQ-VAS at timepoint1 accounted for 34.5% of the variance of EQ-VAS improvement expressed as the difference between timepoint2 and timepoint1. Our study supports HR-QoL imp...Continue Reading

References

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Citations

Nov 9, 2017·Frontiers in Neurology·Daniel WeissTobias Wächter
Dec 15, 2017·International Ophthalmology Clinics·Daniel J Ozzello, Joseph N Giacometti
Apr 16, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M H OsakiA A V Cruz
May 8, 2020·Toxins·Lorenzo Pietro RoncoroniTobias Wächter
May 12, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Nicola TambascoPaolo Calabresi
Nov 21, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xiao-Bo FangWei-Xi Zhang

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Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

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Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

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